| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Fratelli, Caroline Ferreira | - |
| dc.contributor.author | Siqueira, Jhon | - |
| dc.contributor.author | Silva, Calliandra Maria de Souza | - |
| dc.contributor.author | Ferreira, Eduardo Antônio | - |
| dc.contributor.author | Silva, Izabel Cristina Rodrigues da | - |
| dc.date.accessioned | 2021-02-17T13:52:48Z | - |
| dc.date.available | 2021-02-17T13:52:48Z | - |
| dc.date.issued | 2020-10-26 | - |
| dc.identifier.citation | FRATELLI, Caroline et al. 5HTTLPR genetic variant and major depressive disorder: a review. Genes, v. 11, n. 11, 1260, 2020. DOI: https://doi.org/10.3390/genes11111260. Disponível em: https://www.mdpi.com/2073-4425/11/11/1260. Acesso em: 17 fev. 2021. | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/40077 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | MDPI | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | 5HTTLPR genetic variant and major depressive disorder : a review | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Polimorfismo (Genética) | pt_BR |
| dc.subject.keyword | 5HTTLPR | pt_BR |
| dc.subject.keyword | Fatores de risco | pt_BR |
| dc.subject.keyword | Sistema nervoso | pt_BR |
| dc.subject.keyword | Farmacogenômica | pt_BR |
| dc.subject.keyword | Depressão mental | pt_BR |
| dc.rights.license | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | pt_BR |
| dc.identifier.doi | https://doi.org/10.3390/genes11111260 | pt_BR |
| dc.description.abstract1 | Major Depressive Disorder (MDD) is a disease that involves biological, psychological, and
social interactions. Studies have shown the importance of genetics contribution to MDD development.
The SCL6A4 protein (5HTTLPR) functions transporting serotonin, a neurotransmitter linked to mood
and emotion, to the synaptic cleft. Hence, this study seeks, through a literature review, a better
comprehension of the 5HTTLPR genetic variant association with MDD. For this purpose, a search was
performed on the Virtual Health Library Portal for articles that related 5HTTLPR to MDD. Most of the
articles found were conducted in the American continent, with one (1) study implemented in Brazil.
5HTTLPR associations were found regarding changes in the nervous system, pharmacology, and
risk factors seen in MDD patients. When verifying the allelic distribution, the S allele had a higher
frequency in most of the studies analyzed. Despite not finding a commonality in the different studies,
the tremendous genetic variation found demonstrates the MDD complexity. For this reason, further
studies in diverse populations should be conducted to assist in the understanding and treatment of
the disease. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-0511-9452 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-9064-0735 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0003-1903-1352 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-6836-3583 | pt_BR |
| dc.description.unidade | Faculdade UnB Ceilândia (FCE) | pt_BR |
| dc.description.ppg | Programa de Pós-Graduação em Ciências e Tecnologias em Saúde | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
|
