Título:	Association of vitamin D with the TaqI polymorphism of the VDR gene in older women attending the basic health unit of the Federal District, DF (Brazil)
Autor(es):	Freitas, Renata de Souza Fratelli, Caroline Ferreira Silva, Calliandra Maria de Souza Lima, Luciano Ramos de Stival, Marina Morato Silva, Izabel Cristina Rodrigues da Funghetto, Silvana Schwerz
ORCID:	https://orcid.org/0000-0003-3563-6415 https://orcid.org/0000-0002-0511-9452 https://orcid.org/0000-0002-9064-0735 https://orcid.org/0000-0002-2709-6335 https://orcid.org/0000-0001-6830-4914 https://orcid.org/0000-0002-6836-3583 https://orcid.org/0000-0002-9332-9029
Assunto:	Vitamina D Envelhecimento Vitaminas - carência Polimorfismo (Genética)
Data de publicação:	24-Set-2020
Editora:	Hindawi
Referência:	FREITAS, Renata de Souza et al. Association of vitamin D with the TaqI polymorphism of the VDR gene in older women attending the basic health unit of the Federal District, DF (Brazil). Journal of Aging Research, v. 2020, Article ID 7145193, 2020. DOI: https://doi.org/10.1155/2020/7145193. Disponível em: https://www.hindawi.com/journals/jar/2020/7145193/. Acesso em: 10 dez. 2020.
Abstract:	Aging is accompanied by various functional modifications determined by their environment, lifestyle, nutrition, and genetics. Based on these factors, it is essential to verify the vitamin deficiency in the elderly population. Hypovitaminosis D is commonly present in human aging, increasing the chances of developing noncommunicable chronic diseases. The VDR gene TaqI polymorphism may modify the vitamin D metabolic pathway by altering the interaction between the vitamin D receptor and the active circulating vitamin D. Therefore, this study aimed to investigate the association between serum vitamin D and biochemical and genetic factors, considering the TaqI polymorphism of the VDR gene, in an elderly population of the Federal District. The study was a descriptive, case-control, quantitative, and cross-sectional type and was conducted in two basic health units in the administrative region of Ceilândia, Federal District, DF, Brazil, with women aged 60 years or older. Anthropometric, biochemical, and genetic parameters (VDR TaqI polymorphism) were evaluated. The adopted significance level was 5%, and statistical analyses were performed using the SPSS version 20.0 program. The study consisted of 128 participants. The most prevalent age was from 60 to 65 years (N = 53; 41.4%). 66 elderly (51.6%) were part of the case group (hypovitaminosis D), while 62 were in the control group. In the case group, 30.2% had grade I obesity, 77.3% were hypertensive, and 51.5% were diabetic. The TT genotype was present in 47% of the case group and 54.8% in the control group (). There was no association between serum vitamin D levels and the VDR gene variant TaqI polymorphism in an elderly Brazilian population.
Unidade Acadêmica:	Faculdade UnB Ceilândia (FCE)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde
Licença:	Copyright © 2020 Renata de Souza Freitas et al.(is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI:	https://doi.org/10.1155/2020/7145193
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