Title:	ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19
Authors:	Zipeto, Donato Palmeira, Julys da Fonseca Argañaraz, Gustavo Adolfo Argañaraz, Enrique Roberto
Assunto::	ADAM17 ACE2 TMPRSS2 SARS-CoV-2 Covid-19
Issue Date:	7-Oct-2020
Publisher:	Frontiers
Citation:	ZIPETO, Donato et al. ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19. Frontiers in Immunology, v. 11, art. 576745, out. 2020. DOI: https://doi.org/10.3389/fimmu.2020.576745. Disponível em: https://www.frontiersin.org/articles/10.3389/fimmu.2020.576745/full. Acesso em: 16 nov. 2020.
Abstract:	The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and chronic lung disease have been identified as the main COVID-19 comorbidities. Moreover, despite similar infection rates between men and women, the most severe course of the disease is higher in elderly and co-morbid male patients. Therefore, the occurrence of specific comorbidities associated with renin–angiotensin system (RAS) imbalance mediated by the interaction between angiotensin-converting enzyme 2 (ACE2) and desintegrin and metalloproteinase domain 17 (ADAM17), along with specific genetic factors mainly associated with type II transmembrane serine protease (TMPRSS2) expression, could be decisive for the clinical outcome of COVID-19. Indeed, the exacerbated ADAM17—mediated ACE2, TNF-α, and IL-6R secretion emerges as a possible underlying mechanism for the acute inflammatory immune response and the activation of the coagulation cascade. Therefore, in this review, we focus on the main pathophysiological aspects of ACE2, ADAM17, and TMPRSS2 host proteins in COVID-19. Additionally, we discuss a possible mechanism to explain the deleterious effect of ADAM17 and TMPRSS2 over-activation in the COVID-19 outcome.
Licença::	Copyright © 2020 Zipeto, Palmeira, Argañaraz and Argañaraz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI:	https://doi.org/10.3389/fimmu.2020.576745
Appears in Collections:	Artigos publicados em periódicos e afins UnB - Covid-19

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