Título:	Potential neuroprotective and antiinfammatory efects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells
Autor(es):	Melo, Heloísa Antoniella Braz de Nascimento, Gabriel Pasquarelli do Corrêa, Rafael Almeida, Raquel das Neves Santos, Igor de Oliveira Prado, Paulo Sousa Picolo, Victor Bem, Andreza Fabro de Pizato, Nathalia Marcolini Pelucio Magalhães, Kelly Grace
Assunto:	Ômega 3 Zika vírus
Data de publicação:	27-Dez-2019
Editora:	Nature Research
Referência:	MELO, Heloísa Antoniella Braz de et al. Potential neuroprotective and antiinfammatory efects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells. Scientific Reports, v. 9, 20119, 2019. DOI: https://doi.org/10.1038/s41598-019-56556-y. Disponível em: https://www.nature.com/articles/s41598-019-56556-y. Acesso em: 11 nov. 2020.
Abstract:	Zika virus (ZIKV) has a strong tropism for the nervous system and has been related to post-infection neurological syndromes. Once neuronal cells are infected, the virus is capable of modulating cell metabolism, leading to neurotoxicity and cellular death. The negative efect of ZIKV in neuron cells has been characterized. However, the description of molecules capable of reversing these cytotoxic efects is still under investigation. In this context, it has been largely demonstrated that docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, is highly neuroprotective. Here, we hypothesized that DHA’s neuroprotective proprieties could have an infuence on ZIKV-induced neurotoxicity in SHSY5Y cells. Our data showed that pre-treatment of SH-SY5Y cells with DHA increased the cell viability and proliferation in ZIKV-infected cells. Moreover, DHA triggered an anti-infammatory response in those infected cells. Besides, DHA was capable of restoring mitochondria function and number in ZIKVinfected SH-SY5Y cells. In addition, cells pre-treated with DHA prior to ZIKV infection presented a lower viral load at diferent times of infection. Taking together, these results demonstrated that DHA has a potential anti-infammatory and neuroprotective efect against ZIKV infection in these neuron-like cells and could be a useful tool in the treatment against this virus.
Licença:	(CC BY) - Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2019
DOI:	https://doi.org/10.1038/s41598-019-56556-y
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