The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases

Tolentino, Seila; Pereira, Maira N.; Sousa, Mikaella C. de; Cunha Filho, Marcílio Sérgio Soares da; Gelfuso, Guilherme Martins; Gratieri, Taís

Registro completo de metadados

Campo DC	Valor	Idioma
dc.contributor.author	Tolentino, Seila	-
dc.contributor.author	Pereira, Maira N.	-
dc.contributor.author	Sousa, Mikaella C. de	-
dc.contributor.author	Cunha Filho, Marcílio Sérgio Soares da	-
dc.contributor.author	Gelfuso, Guilherme Martins	-
dc.contributor.author	Gratieri, Taís	-
dc.date.accessioned	2020-10-13T17:19:18Z	-
dc.date.available	2020-10-13T17:19:18Z	-
dc.date.issued	2020	-
dc.identifier.citation	TOLENTINO, Seila et al. The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases. Journal of Drug Delivery Science and Technology, v. 59, 101895, 2020. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S1773224720311849.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/39538	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Elsevier	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Fosfato de clindamicina	pt_BR
dc.subject.keyword	Doença folicular	pt_BR
dc.subject.keyword	Folículo capilar	pt_BR
dc.subject.keyword	Nanopartículas	pt_BR
dc.subject.keyword	Pele	pt_BR
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/abs/pii/S1773224720311849	pt_BR
dc.description.abstract1	Nanostructures have been proposed as drug delivery systems in the treatment of hair follicle-related conditions because of their well-reported tendency to accumulate into the hair follicle shafts extending drug release. However, little is known about colloids behavior under diseased conditions as acne vulgaris, folliculitis, hidradenitis suppurativa, or capillary keratosis, in which there is an excess of sebum secretion that clogs the hair follicles. Here, we evaluated the influence of the sebaceous content on the performance of nanosystems by using an in vitro sebaceous skin model, in which the skin was massaged with a mixture of mutton tallow and vegetable oil in a 1:1 (w/w) preceding the permeation experiments. A nanostructured lipid carrier containing clindamycin phosphate (~90% of encapsulation efficiency) was used as a formulation model. Nanoparticles presented a mean diameter of 391.9 ± 8.6 nm, PDI of 0.16 ± 0.05, and positive zeta potential (+18.5 ± 1.5 mV). Stability studies confirmed nanoparticles were stable throughout all experiments, and drug release studies confirmed the controlled release profile. The results indicated the nanosystem performance was superior to the free drug in targeting the hair follicle in conventional skin permeation experiments, but no advantages of the colloidal system were observed when using the sebaceous skin model. Hence, the sebaceous content hampered nanoparticles deposition into the hair follicle shafts. In conclusion, the physiological skin condition must be considered when designing targeted drug delivery systems. The novel sebaceous skin model proposed in this paper can be used to evaluate, in a more realistic condition, the performance of the nanostructured systems intended for topical drug delivery in conditions of excess sebaceous secretion.	pt_BR
Aparece nas coleções:	Artigos publicados em periódicos e afins