Título:	The impact of the adipose organ plasticity on inflammation and cancer progression
Autor(es):	Corrêa, Luís Henrique Heyn, Gabriella Simões Magalhães, Kelly Grace
ORCID:	https://orcid.org/0000-0003-2825-0127 https://orcid.org/0000-0001-7120-1086 https://orcid.org/0000-0002-7435-5272
Assunto:	Tecido adiposo Tecido adiposo marrom Escurecimento Câncer
Data de publicação:	30-Jun-2019
Editora:	MDPI
Referência:	CORRÊA, Luís Henrique; HEYN, Gabriella Simões; MAGALHÃES, Kelly Grace. The impact of the adipose organ plasticity on inflammation and cancer progression. Cells, v. 8, n. 7, 662, 2019. DOI: https://doi.org/10.3390/cells8070662. Disponível em: https://www.mdpi.com/2073-4409/8/7/662. Acesso em: 07 out. 2020.
Abstract:	Obesity is characterized by chronic and low-grade systemic inflammation, an increase of adipose tissue, hypertrophy, and hyperplasia of adipocytes. Adipose tissues can be classified into white, brown, beige and pink adipose tissues, which display different regulatory, morphological and functional characteristics of their adipocyte and immune cells. Brown and white adipocytes can play a key role not only in the control of energy homeostasis, or through the balance between energy storage and expenditure, but also by the modulation of immune and inflammatory responses. Therefore, brown and white adipocytes can orchestrate important immunological crosstalk that may deeply impact the tumor microenvironment and be crucial for cancer establishment and progression. Recent works have indicated that white adipose tissues can undergo a process called browning, in which an inducible brown adipocyte develops. In this review, we depict the mechanisms involved in the differential role of brown, white and pink adipocytes, highlighting their structural, morphological, regulatory and functional characteristics and correlation with cancer predisposition, establishment, and progression. We also discuss the impact of the increased adiposity in the inflammatory and immunological modulation. Moreover, we focused on the plasticity of adipocytes, describing the molecules produced and secreted by those cells, the modulation of the signaling pathways involved in the browning phenomena of white adipose tissue and its impact on inflammation and cancer.
Licença:	© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DOI:	https://doi.org/10.3390/cells8070662
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