Título:	Bariatric surgery and vitamin d: trends in older women and association with clinical features and vdr gene polymorphisms
Autor(es):	Benito, Linconl Agudo Oliveira Kogawa, Evelyn Mikaela Silva, Calliandra Maria de Souza Melo, Fabíola Ferreira Sales-Peres, Silvia Helena de Carvalho Silva, Izabel Cristina Rodrigues da Karnikowski, Margô Gomes de Oliveira
ORCID:	https://orcid.org/0000-0002-9064-0735 https://orcid.org/0000-0003-3811-7899 https://orcid.org/0000-0002-6836-3583 https://orcid.org/0000-0002-5662-2058
Afiliação do autor:	Graduate Program in Health Sciences and Technologies, Faculty of Ceilandia, University of Brasília, Federal District, Brasília 72220-275, DF, Brazil University of São Paulo (USP), Bauru School of Dentistry Department of Dentistry, School of Health Sciences, University of Brasília, Brasília 70.910-900, DF, Brazil University of Brasília, Faculty of Ceilandia, Graduate Program in Health Sciences and Technologies Department of Dentistry, School of Health Sciences, University of Brasília, Brasília 70.910-900, DF, Brazil University of São Paulo, Bauru School of Dentistry University of Brasília, Faculty of Ceilandia, Graduate Program in Health Sciences and Technologies University of Brasília, Faculty of Ceilandia, Graduate Program in Health Sciences and Technologies
Assunto:	Cirurgia bariátrica Vitamina D Mulheres idosas Polimorfismo Fokl Polimorfismo Taql
Data de publicação:	4-Fev-2023
Editora:	MDPI AG
Referência:	BENITO, Linconl Agudo Oliveira et al. Bariatric surgery and vitamin d: trends in older women and association with clinical features and vdr gene polymorphisms. Nutrients, [S. l.], v. 15, n. 4, 799, 2023. DOI: https://doi.org/10.3390/nu15040799. Disponível em: https://www.mdpi.com/2072-6643/15/4/799. Acesso em: 9 set. 2026.
Abstract:	(1) Background: Obesity and its comorbidities can cause burdens and limitations. Bariatric surgery (BS) is indicated as a safe procedure to reduce body mass and improve present comorbidities. However, several complications were reported, such as vitamin D [25(OH)D] deficiency. We evaluated if 25(OH)D serum levels relate to clinical characteristics, symptoms, or habits in women after their BS, and whether the vitamin D receptor (VDR) gene’s TaqI and FokI polymorphisms affected 25(OH)D levels and the total body bone mineral density (TBBMD). (2) Methods: This cohort cross-sectional comparative analytical prospective study consisted of 27 women, 61.6 ± 5.0 years, submitted to BS one year prior at a public reference hospital, DF-Brazil. All participants were asked to follow the physical and dietary activity recommendations and received vitamin D3 supplements. Their anthropometric, biochemical, and immunological measurements and blood samples were obtained. (3) Results: 73.3% of participants had low 25(OH)D levels, and their levels correlated positively with TBBMD and negatively with systolic pressure. VDR TaqI did not affect 25(OH)D levels, whereas VDR FokI’s allele f presence correlated to a median rise in 25(OH)D levels. Neither polymorphism correlated to TBBMD. (4) Conclusions: 25(OH)D levels were positively correlated with TBBMD, negatively with systolic blood pressure, and were higher in those with the VDR FokI allele f.
Unidade Acadêmica:	Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde
DOI:	https://doi.org/10.3390/nu15040799
Aparece nas coleções:	Artigos publicados em periódicos e afins

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