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dc.contributor.authorLeão, Mayra Cardoso Coutopt_BR
dc.contributor.authorFagg, Christopher Williampt_BR
dc.contributor.authorSimeoni, Luiz Albertopt_BR
dc.contributor.authorHomem de Mello, Mauriciopt_BR
dc.contributor.authorMagalhães, Pérola Oliveirapt_BR
dc.contributor.authorSilveira, Damarispt_BR
dc.contributor.authorBazzo, Yris Maria Fonsecapt_BR
dc.date.accessioned2026-07-30T14:18:48Z-
dc.date.available2026-07-30T14:18:48Z-
dc.date.issued2025-7pt_BR
dc.identifier.citationLEÃO, Mayra Cardoso Couto; FAGG, Christopher William; SIMEONI, Luiz Alberto; HOMEM-DE-MELLO, Mauricio; MAGALHÃES, Pérola Oliveira; SILVEIRA, Damaris; FONSECA-BAZZO, Yris Maria. Hepatoprotective potential of some species of Erythroxylum, Eugenia and Pouteria genera from Brazilian savanna against acetaminophen-induced liver injury. Natural Product Communications, [S. l.], v. 20, n. 7, 2025. DOI: https://doi.org/10.1177/1934578x251360959. Disponível em: https://journals.sagepub.com/doi/full/10.1177/1934578X251360959#con1. Acesso em: 30 jul. 2026.pt_BR
dc.identifier.urihttps://doi.org/10.1177/1934578X251360959pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/55542-
dc.language.isoengpt_BR
dc.publisherSAGE Publicationspt_BR
dc.rightsAcesso Abertopt_BR
dc.titleHepatoprotective potential of some species of Erythroxylum, Eugenia and Pouteria genera from Brazilian savanna against acetaminophen-induced liver injurypt_BR
dc.typeArtigopt_BR
dc.subject.keywordParacetamolpt_BR
dc.subject.keywordFitoterapiapt_BR
dc.subject.keywordAtividade hepatoprotetorapt_BR
dc.rights.license(CC BY NC) Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub. com/en-us/nam/open-access-at-sage).pt_BR
dc.identifier.doihttps://doi.org/10.1177/1934578x251360959pt_BR
dc.description.abstract1Objectives Liver injury is a major global public health concern. Despite advancements in modern medicine, there remains a pressing need to identify more effective and less toxic therapeutic options for managing liver diseases. This study aimed to assess the hepatoprotective potential of Erythroxylum daphnites Mart., Erythroxylum suberosum A.St.-Hil., Eugenia dysenteria (Mart.) DC., Pouteria torta (Mart.) Radlk., and Pouteria ramiflora (Mart.) Radlk. against acetaminophen (APAP)-induced injury in human hepatocarcinoma (HepG2) cells. Methods The hepatoprotective potential of the extracts was evaluated in HepG2 cells using APAP as the injury-inducing agent. Additionally, the chemical composition of the extracts was analyzed using high-performance liquid chromatography coupled with diode-array detection (HPLC-DAD). Results Chemical analysis of the plant extracts revealed the presence of polyphenolic compounds, including flavonoids and phenolic acids. All tested extracts exhibited a significant protective effect against APAP-induced cell death in both pre-treatment and post-treatment protocols. Conclusion This study highlights the potential of natural products from the Cerrado biome as hepatoprotective agents. The observed protective effects are likely attributed to the diverse chemical compounds present in these extracts.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6072-7832pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3401-290Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4541-9177pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8011-6940pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1851-5224pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1230-3207pt_BR
dc.contributor.affiliationUniversity of Brasíliapt_BR
dc.contributor.affiliationUniversity of Brasíliapt_BR
dc.contributor.affiliationUniversity of Brasíliapt_BR
dc.contributor.affiliationUniversity of Brasíliapt_BR
dc.contributor.affiliationUniversity of Brasíliapt_BR
dc.contributor.affiliationUniversity of Brasíliapt_BR
dc.contributor.affiliationUniversity of Brasíliapt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências Farmacêuticas-
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