| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Oliveira, Gabriel de Sousa | - |
| dc.contributor.author | Barreto, Livia Cristina Lira de Sá | - |
| dc.contributor.author | Lima, Ana Luiza | - |
| dc.contributor.author | Gross, Idejan Padilha | - |
| dc.contributor.author | Pinho, Ludmila Alvim Gomes | - |
| dc.contributor.author | Souza, Patrícia Medeiros | - |
| dc.contributor.author | Gratieri, Taís | - |
| dc.contributor.author | Gelfuso, Guilherme Martins | - |
| dc.contributor.author | Cunha Filho, Marcílio Sérgio Soares da | - |
| dc.date.accessioned | 2026-07-30T11:06:49Z | - |
| dc.date.available | 2026-07-30T11:06:49Z | - |
| dc.date.issued | 2026-03-25 | - |
| dc.identifier.citation | OLIVEIRA, Gabriel S. et al. 3D-printed detachable tablets for flexible dosing in personalized medicine: influence of score geometry and printing technology. Journal of Drug Delivery Science and Technology, [S. l.], V. 120, 108278, 2026. DOI: http://doi.org/10.1016/j.jddst.2026.108278. Disponível em: https://www.sciencedirect.com/science/article/pii/S1773224726003035?via%3Dihub. Acesso em: 30 jul. 2026. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/55539 | - |
| dc.language.iso | eng | pt_BR |
| dc.publisher | Elsevier B. V. | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | 3D-printed detachable tablets for flexible dosing in personalized medicine : influence of score geometry and printing technology | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Impressão 3D | pt_BR |
| dc.subject.keyword | Medicina personalizada | pt_BR |
| dc.subject.keyword | Modelagem de deposição fundida | pt_BR |
| dc.subject.keyword | Jato de ligante | pt_BR |
| dc.subject.keyword | Comprimido destacável | pt_BR |
| dc.rights.license | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | pt_BR |
| dc.identifier.doi | http://doi.org/10.1016/j.jddst.2026.108278 | pt_BR |
| dc.description.abstract1 | Tablet subdivision is widely used for dosage adjustment, particularly in pediatrics and geriatrics, but conven
tional splitting often leads to poor dose uniformity, increased friability, and stability issues. This study explored
the feasibility of two leading 3D printing technologies, fused deposition modeling (FDM) and binder jetting (BJ),
for producing detachable tablets specifically designed for accurate subdivision. Tablets were designed with
distinct score geometries (continuous and dotted) and fabricated using PVA (FDM) or calcium sulfate (BJ). In
addition, a representative drug-loaded FDM sample was also evaluated. BJ tablets were further treated with
saline to enhance structural cohesion. The printed dosage forms were systematically characterized for mass
variation, mass loss, friability, pore volume, and morphology. Results demonstrated that FDM tablets achieved
the highest performance, with mass variation consistently below 2% and negligible mass loss (<0.1%), even after
subdivision into eighths, with comparable subdivision accuracy observed for the drug-loaded formulation. BJ
tablets showed greater variability but achieved acceptable results when optimized with dotted-score design and
saline post-treatment, with friability values (~0.3%), well below the 1% pharmacopeial limit. Morphological
analyses confirmed improved cohesion and reduced porosity after post-treatment. Overall, these findings
demonstrate the potential of 3D printing to overcome the limitations of conventional tablet splitting by enabling
dosage forms specifically engineered for accurate and reproducible subdivision. This approach may complement
both individualized and large-scale pharmaceutical manufacturing scenarios. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0009-0005-7175-164X | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-2177-8941 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-9167-6852 | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs, and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs, and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs, and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs, and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs, and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs, and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs, and Cosmetics | pt_BR |
| dc.description.unidade | Faculdade de Ciências da Saúde (FS) | pt_BR |
| dc.description.unidade | Departamento de Farmácia (FS FAR) | pt_BR |
| dc.description.unidade | Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia | - |
| dc.description.ppg | Programa de Pós-Graduação em Ciências da Saúde | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
|
