Título:	MiR-20a is upregulated in serum from domestic feline with PKD1 mutation
Autor(es):	Scalon, Marcela Corrêa Martins, Christine Souza Ferreira, Gabriel Ginani Schlemmer, Franciele Almeida, Ricardo Titze de Paludo, Giane Regina
ORCID:	https://orcid.org/0000-0002-9112-1718
Afiliação do autor:	University of Brasília, College of Agronomy and Veterinary Medicine, Veterinary Clinical Pathology Laboratory University of Brasília, College of Agronomy and Veterinary Medicine, Veterinary Clinical Pathology Laboratory University of Brasília, College of Agronomy and Veterinary Medicine, Technology for Gene Therapy Laboratory University of Brasília, College of Agronomy and Veterinary Medicine, Technology for Gene Therapy Laboratory University of Brasília, College of Agronomy and Veterinary Medicine, Technology for Gene Therapy Laboratory University of Brasília, College of Agronomy and Veterinary Medicine, Veterinary Clinical Pathology Laboratory
Assunto:	Gato - doenças Animais domésticos - doenças Plasma Doença renal policística
Data de publicação:	20-Dez-2022
Editora:	Public Library of Science (PLoS)
Referência:	SCALON, Marcela Correa; MARTINS, Christine Souza; FERREIRA, Gabriel Ginani; SCHLEMMER, Franciele; ALMEIDA, Ricardo Titze de; PALUDO, Giane Regina. MiR-20a is upregulated in serum from domestic feline with PKD1 mutation. PLOS ONE, San Francisco, v. 17, n. 12, p. e0279337, 2022. DOI https://doi.org/10.1371/journal.pone.0279337. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0279337. Acesso em: 11 jun. 2026.
Abstract:	Polycystic kidney disease (PKD), also known as autosomal dominant polycystic kidney disease (ADPKD) is a genetically heterogeneous condition characterized by cysts in renal parenchyma. It is the most prevalent inherited disease of domestic cats. MicroRNAs (miRNAs or ncRNA) are short, noncoding, single-stranded RNAs that may induce PKD cytogenesis by affecting numerous targets genes as well as by directly regulating PKD gene expression. We compared the relative expression profile of miR-20a, -192, -365, -15b-5p, and -16-5p from plasma and serum samples of nine domestic cats with PKD1 mutation, detected by polymerase chain reaction (PCR), and a control group (n = 10). Blood samples from cats with PKD1 mutation provide similar concentrations of microRNAs either from plasma or serum. Serum miR-20a is upregulated in PKD group with p < 0.005; Roc curve analysis showed an AUC of 90,1% with a cut-off value sensitivity of 77.8% and specificity of 100%. This data provides important information regarding renal miRNA expression in peripheral blood sampling.
Unidade Acadêmica:	Faculdade de Agronomia e Medicina Veterinária (FAV)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências Animais
Licença:	This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FONTE: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0279337. Acesso em: 11 jun. 2026.
DOI:	https://doi.org/10.1371/journal.pone.0279337
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