Titre:	Lipid metabolism modulation during SARS-CoV-2 infection : a spotlight on extracellular vesicles and therapeutic prospects
Auteur(s):	D’Avila, Heloisa Lima, Claudia Natércia Rocha Rampinelli, Pollianne Garbero Mateus, Laiza Camila Oliveira Silva, Renata Vieira de Sousa Corrêa, José Raimundo Almeida, Patrícia Elaine de
metadata.dc.identifier.orcid:	https://orcid.org/0009-0005-7842-9389 https://orcid.org/0000-0001-9785-8246 https://orcid.org/0000-0003-2752-5395 https://orcid.org/0000-0002-9081-8601
metadata.dc.contributor.affiliation:	Federal University of Juiz de Fora, Department of Biology, Cell Biology Laboratory University of Brasília, Laboratory of Microscopy and Microanalysis Federal University of Juiz de Fora, Department of Biology, Cell Biology Laboratory Federal University of Juiz de Fora, Department of Biology, Cell Biology Laboratory Federal University of Juiz de Fora, Department of Biology, Cell Biology Laboratory University of Brasília, Laboratory of Microscopy and Microanalysis Federal University of Juiz de Fora, Department of Biology, Cell Biology Laboratory
Assunto::	Vesículas extracelulares Metabolismo lipídico Gotas lipídicas Infecções por SARS-CoV-2 Covid-19
Date de publication:	4-jan-2024
Editeur:	MDPI
Référence bibliographique:	D’AVILA, Heloisa et al. Lipid metabolism modulation during SARS-CoV-2 infection: a spotlight on extracellular vesicles and therapeutic prospects. International Journal of Molecular Sciences, Basel, v. 25, n. 1, e640, 2024. DOI: https://doi.org/10.3390/ijms25010640. Disponível em: https://www.mdpi.com/1422-0067/25/1/640. Acesso em: 10 jul. 2025.
Abstract:	Extracellular vesicles (EVs) have a significant impact on the pathophysiological processes associated with various diseases such as tumors, inflammation, and infection. They exhibit molecular, biochemical, and entry control characteristics similar to viral infections. Viruses, on the other hand, depend on host metabolic machineries to fulfill their biosynthetic requirements. Due to potential advantages such as biocompatibility, biodegradation, and efficient immune activation, EVs have emerged as potential therapeutic targets against the SARS-CoV-2 infection. Studies on COVID-19 patients have shown that they frequently have dysregulated lipid profiles, which are associated with an increased risk of severe repercussions. Lipid droplets (LDs) serve as organelles with significant roles in lipid metabolism and energy homeostasis as well as having a wide range of functions in infections. The down-modulation of lipids, such as sphingolipid ceramide and eicosanoids, or of the transcriptional factors involved in lipogenesis seem to inhibit the viral multiplication, suggesting their involvement in the virus replication and pathogenesis as well as highlighting their potential as targets for drug development. Hence, this review focuses on the role of modulation of lipid metabolism and EVs in the mechanism of immune system evasion during SARS-CoV-2 infection and explores the therapeutic potential of EVs as well as application for delivering therapeutic substances to mitigate viral infections.
metadata.dc.description.unidade:	Instituto de Ciências Biológicas (IB) Departamento de Biologia Celular (IB CEL)
Licença::	(CC BY) Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
DOI:	https://doi.org/10.3390/ijms25010640
Collection(s) :	Artigos publicados em periódicos e afins

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