Título:	Avaliação do uso tópico de vesículas extracelulares na cicatrização de feridas cutâneas em suínos
Autor(es):	Argenta, Verônica Lourença de Souza
Orientador(es):	Ximenes, Fábio Henrique Bezerra
Assunto:	Terapia celular Suíno - doenças Células-tronco mesenquimais
Data de publicação:	26-Jul-2022
Data de defesa:	22-Dez-2024
Referência:	ARGENTA, Verônica Lourença de Souza. Avaliação do uso tópico de vesículas extracelulares na cicatrização de feridas cutâneas em suínos. 2022. 104 f., il. Dissertação (Mestrado em Saúde Animal) — Universidade de Brasília, Brasília, 2022.
Abstract:	Present in cell therapy, mesenchymal stem cells (MSCs) are undifferentiated cells, defined by their great capacity for proliferation, self-renewal and regeneration after injury. They can be classified in different ways, according to their tissue of origin, such as embryonic, adult, and induced pluripotent stem cells, and their capacity for cell differentiation, such as totipotent, pluripotent, or multipotent cells. Initially, it was thought that MSCs exerted their therapeutic effect by migrating to the site of injury, inserting themselves and subsequently differentiating into cells desired for tissue regeneration. However, studies have indicated that the therapeutic benefit of MSCs is attributed not only to their differentiation, but also to the factors they secrete, such as growth factors, chemokines and cytokines, in addition to releasing numerous extracellular vesicles that participate in tissue regeneration through transfer information to damaged cells or tissues. The present work aims to evaluate the healing effect of cutaneous wounds, produced on the back of three healthy pigs, obtained in different concentrations of isolated extracellular vesicles, cultivated and characterized through MSCs of swine adipose tissue, during twenty-eight days . Sixteen cutaneous wounds were made on the back of each pig, in duplicate, we used two different concentrations of extracellular vesicles, one of healing base, one of conditioned medium, positive control that was used a commercial ointment and negative control, using solution saline. Quantitative data were measured through wound retraction and qualitative data were performed through histological slides. Concluding significant therapeutic effect on tissue repair of extracellular vesicles
Unidade Acadêmica:	Faculdade de Agronomia e Medicina Veterinária (FAV)
Informações adicionais:	Dissertação (Mestrado em Saúde Animal) — Universidade de Brasília, Faculdade de Agronomia e Medicina Veterinária, Programa de Pós-graduação em Saúde Animal, Brasília, 2022.
Programa de pós-graduação:	Programa de Pós-Graduação em Saúde Animal
Aparece nas coleções:	Teses, dissertações e produtos pós-doutorado

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