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dc.contributor.authorLima, Camilla Pedrosa Vieira-
dc.contributor.authorGrisi, Daniela Corrêa-
dc.contributor.authorGuimarães, Maria do Carmo Machado-
dc.contributor.authorSalles, Loise Pedrosa-
dc.contributor.authorKruly, Paula de Castro-
dc.contributor.authorThuy Do-
dc.contributor.authorBorges, Luiz Gustavo dos Anjos-
dc.contributor.authorTeixeira, Nailê Dame-
dc.identifier.citationLIMA, Camilla Pedrosa Vieira et al. Enrichment of sulphate-reducers and depletion of butyrate-producers may be hyperglycaemia signatures in the diabetic oral microbiome. Journal of Oral Microbiology, [S.l.], v. 14, n. 1, 2082727, 2022. DOI: Disponível em: Acesso em: 10 ago. 2022.pt_BR
dc.publisherInforma UK Limitedpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleEnrichment of sulphate-reducers and depletion of butyrate-producers may be hyperglycaemia signatures in the diabetic oral microbiomept_BR
dc.subject.keywordMicrobioma oralpt_BR
dc.rights.licenseThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.pt_BR
dc.description.abstract1Objectives: This study aimed to investigate oral microbial signatures associated with hyperglycaemia, by correlating the oral microbiome with three glycaemic markers. Potential association between clinical parameters and oral bacterial taxa that could be modulating the hyperglycaemic microbiome was also explored. Methods: Twenty-three individuals diagnosed with type 2 Diabetes Mellitus (T2D) and presenting periodontitis were included, as well as 25 systemically and periodontally healthy ones. Fasting blood glucose, glycated haemoglobin, salivary glucose, periodontitis classification, caries experience and activity and salivary pH were evaluated. The V4 region of the 16S rRNA gene was amplified from total salivary DNA, and amplicons were sequenced (Illumina MiSeq). Results: Hyperglycaemia was correlated with proportions of Treponema, Desulfobulbus, Phocaiecola and Saccharimonadaceae. Desulfobulbus was ubiquitous and the most enriched organism in T2D individuals (log2FC = 4). The Firmicutes/Bacteroidetes ratio was higher at alkali salivary pH than acidic pH. In the network analysis, Desulfobulbus was clustered in a negative association with caries-associated and butyrate-producing bacteria. Conclusion: The salivary microbiome is shaped by systemic hyperglycaemia, as well as changes in the salivary pH, which may be linked to local hyperglycaemia. The enrichment of predictive biomarkers of gut dysbiosis in the salivary microbiome can reflect its capacity for impairment of hyperglycaemia.pt_BR
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