Application of hot-melt extrusion in the complexation of naringenin with cyclodextrin using hydrophilic polymers

Granados, Pedro A.; Pinho, Ludmila Alvim Gomes; Barreto, Livia Cristina Lira de Sá; Gratieri, Taís; Gelfuso, Guilherme Martins; Cunha Filho, Marcílio Sérgio Soares da

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Campo DC	Valor	Lengua/Idioma
dc.contributor.author	Granados, Pedro A.	-
dc.contributor.author	Pinho, Ludmila Alvim Gomes	-
dc.contributor.author	Barreto, Livia Cristina Lira de Sá	-
dc.contributor.author	Gratieri, Taís	-
dc.contributor.author	Gelfuso, Guilherme Martins	-
dc.contributor.author	Cunha Filho, Marcílio Sérgio Soares da	-
dc.date.accessioned	2022-04-05T12:27:47Z	-
dc.date.available	2022-04-05T12:27:47Z	-
dc.date.issued	2022	-
dc.identifier.citation	GRANADOS, Pedro A. et al. Application of hot-melt extrusion in the complexation of naringenin with cyclodextrin using hydrophilic polymers. Advanced Powder Technology, v. 33, n. 1,103380, jan. 2022. DOI: https://doi.org/10.1016/j.apt.2021.11.032. Disponível em: https://www.sciencedirect.com/science/article/pii/S0921883121005690?via%3Dihub.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/43335	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Elsevier B.V. and The Society of Powder Technology Japan	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Application of hot-melt extrusion in the complexation of naringenin with cyclodextrin using hydrophilic polymers	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Naringenina	pt_BR
dc.subject.keyword	Análise térmica	pt_BR
dc.subject.keyword	Extrusão de derretimento	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.apt.2021.11.032	pt_BR
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0921883121005690?via%3Dihub	pt_BR
dc.description.abstract1	The complexation of cyclodextrin ranks among the best methods of overcoming the unfavorable pharma cokinetic properties of naringenin (NAR). This work proposes obtaining NAR complexes with hydroxypropyl-b-cyclodextrin (HPbCD) using hot-melt extrusion (HME), a solvent-free, continuous man ufacturing process. To that end, the miscibility and stability of NAR in different hydrophilic polymeric matrices were tested using thermal, morphological, and spectroscopic assays, after which inclusion com plexes were prepared via HME using different plasticizers. While the cellulosic polymers showed a lim ited ability to dissolve NAR, Plasdone! S-630 was chemically incompatible with the drug under shearing and heating. By contrast, polyvinyl alcohol and Soluplus! demonstrated compatibility and a high capacity to interact with NAR. The polyvinyl alcohol extrudates accelerated NAR’s dissolution, especially in sys tems containing HPbCD, which suggests high levels of the inclusion complex’s formation and nearly instantaneous dissolution (28 mg/mL in 15 min) superior to other technological approaches described in the literature. Meanwhile, samples extruded with Soluplus! delayed NAR’s dissolution, with rates modulated according to the drug–cyclodextrin interaction. Thus, HME proved to be a valuable, versatile method of producing cyclodextrin complexes of NAR able to support immediate and prolonged drug delivery systems depending on the formulation parameters. Many industrial advantages, including being eco-friendly and easy to scale up, make HME a promising method for exploring NAR’s remarkable medical potential.	pt_BR
dc.description.unidade	Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia	pt_BR
dc.description.unidade	Curso de Farmácia (FCTS-FAR)	pt_BR
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