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Universidade de Brasília
Please use this identifier to cite or link to this item: http://repositorio.unb.br/handle/10482/42427
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dc.contributor.authorSilva, Ihatanderson Alves da-
dc.contributor.authorLima, Ana Luiza-
dc.contributor.authorGratieri, Taís-
dc.contributor.authorGelfuso, Guilherme Martins-
dc.contributor.authorBarreto, Lívia Lira Sá-
dc.contributor.authorCunha Filho, Marcílio Sérgio Soares da-
dc.date.accessioned2021-11-24T19:28:34Z-
dc.date.available2021-11-24T19:28:34Z-
dc.date.issued2021-09-20-
dc.identifier.citationSILVA, Ihatanderson A. et al. Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines.Journal of Pharmaceutical Analysis, 2021. DOI: https://doi.org/10.1016/j.jpha.2021.09.010.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/42427-
dc.language.isoInglêspt_BR
dc.publisherElsevier B.V.pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleCompatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicinespt_BR
dc.typeManuscritopt_BR
dc.subject.keywordImpressão 3Dpt_BR
dc.subject.keywordPreformulaçãopt_BR
dc.subject.keywordExtrusão termofusívelpt_BR
dc.subject.keywordAnálise térmicapt_BR
dc.subject.keywordCompatibilidade droga-polímeropt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jpha.2021.09.010pt_BR
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2095177921001118pt_BR
dc.description.abstract1One of the challenges for developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures. This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines, tested regarding their morphology and thermal, crystallographic, and spectroscopic profiles. Generally, despite the strong drug-polymer interactions observed, the chemical stability of the model drugs was preserved under such conditions. In fact, in the metoprolol and Soluplus® composition, the drug's solubilization in the polymer produced a delay in the drug decomposition, suggesting a protective effect of the matrix. Paracetamol and polyvinyl alcohol mixture, in turn, showed unmistakable signs of thermal instability and chemical decomposition, in addition to physical changes. In the presented context, establishing protocols that simulate processing and storage conditions may be decisive for obtaining stable pharmaceutical dosage forms using three-dimensional printing technology.pt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
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