| DC Field | Value | Language |
|---|
| dc.contributor.author | Santos, Débora S. | - |
| dc.contributor.author | Morais, José Athayde Vasconcelos | - |
| dc.contributor.author | Vanderlei, Ísis A. C. | - |
| dc.contributor.author | Santos, Alexandre S. | - |
| dc.contributor.author | Azevedo, Ricardo Bentes de | - |
| dc.contributor.author | Muehlmann, Luis Alexandre | - |
| dc.contributor.author | Pires Junior, Osmindo Rodrigues | - |
| dc.contributor.author | Mortari, Márcia Renata | - |
| dc.contributor.author | Silva, Jaqueline Rodrigues da | - |
| dc.contributor.author | Silva, Sebastião Willian da | - |
| dc.contributor.author | Longo, João Paulo Figueiró | - |
| dc.date.accessioned | 2021-10-20T12:38:22Z | - |
| dc.date.available | 2021-10-20T12:38:22Z | - |
| dc.date.issued | 2020-11-26 | - |
| dc.identifier.citation | SANTOS, Débora S. et al. Oral delivery of fish oil in oil-in-water nanoemulsion: development, colloidal stability and modulatory effect on in vivo inflammatory induction in mice. Biomedicine & Pharmacotherapy, v. 133, 110980, jan. 2021. DOI: https://doi.org/10.1016/j.biopha.2020.110980. Disponível em: https://www.sciencedirect.com/science/article/pii/S0753332220311720. Acesso em: 20 out. 2021. | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/42149 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | Elsevier Masson SAS | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Oral delivery of fish oil in oil-in-water nanoemulsion : development, colloidal stability and modulatory effect on in vivo inflammatory induction in mice | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Nanoemulsão de óleo de peixe | pt_BR |
| dc.subject.keyword | Tratamento | pt_BR |
| dc.subject.keyword | Inflamação | pt_BR |
| dc.rights.license | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | pt_BR |
| dc.identifier.doi | https://doi.org/10.1016/j.biopha.2020.110980 | pt_BR |
| dc.description.abstract1 | To improve the oral absorption of fish oil and test its anti-inflammatory effect, a fish oil nanoemulsion was developed using cis-4,7,10,13,16,19-docosahexaenoic fatty acid as a biomarker for oral administration. The colloidal stability tests of the fish oil nanoemulsion showed an average size of 155.44 nm ± 6.46 (4 °C); 163.04 nm ± 9.97 (25 °C) and polydispersity index 0.22 ± 0.02 (4 °C), 0.21 ± 0.02 (25 °C), indicating systems with low polydispersity and stable droplets. The fish oil nanoemulsion did not alter the cell viability of the RAW 264.7 macrophages and, at a concentration of 0.024 mg/mL, was kinetically incorporated into the cells after 18 h of contact. The nanoemulsion was maintained in the gastrointestinal region for a significantly shorter period of time (p ≤ 0.05) compared to the intake of fish oil in free form. Inflammatory tests demonstrated that nanoemulsion and fish oil showed less (p ≤ 0.05) neutrophil infiltration after 24h of sepsis induction and there was a significant reduction (p ≤ 0.05) in the volume of paw edema in female adult Balb/c mice who received the nanoemulsion diet compared to the other experimental groups (control, formalin, fish oil and sunflower oil). These results indicate that the fish oil nanoemulsion was significantly effective in the dietary conditions tested here, presenting satisfactory responses in the modulation of inflammatory disorders, demonstrating interesting and beneficial nutraceutical effects. | pt_BR |
| Appears in Collections: | Artigos publicados em periódicos e afins
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