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Title: The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy
Authors: Cerqueira, Adara Rodrigues Damasceno
Fratelli, Caroline Ferreira
Duarte, Ligia Canongia de Abreu Cardoso
Pereira, Alexandre Sampaio Rodrigues
Morais, Rafael Martins de
Sobrinho, Alaor Barra Sobrinho
Silva, Calliandra Maria de Souza
Silva, Izabel Cristina Rodrigues da
Oliveira, Jamila Reis de
Assunto:: Polimorfismo genético
Tireóide - câncer
Óxido nítrico
Issue Date: 2020
Publisher: Sage
Citation: CERQUEIRA, Adara Rodrigues Damasceno. The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy. The International Journal of Biological Markers, v. 35, n. 4, p. 87-91, 2020. DOI: Disponível em: Acesso em: 26 jul. 2021.
Abstract: Thyroid cancer is the most common endocrine cancer in the world. Noting that the NOS3 gene polymorphism interferes with nitric oxide production, this study aims to identify and analyze the NOS3 gene polymorphism in the intron 4 region in patients with papillary thyroid cancer. A case-control study was conducted with 31 papillary thyroid cancer patients of both genders who underwent thyroidectomy and treatment with sodium iodide radiopharmaceutical (131I) compared with 81 control patients. Through papillary thyroid cancer, the results were observed, compiled, and analyzed using SPSS version 25.0. The significance level of 5% was adopted. Genotypic frequencies of healthy subjects were in the Hardy-Weinberg equilibrium (P = 0.503). There was a significant genotypic difference between papillary thyroid cancer and healthy individuals (P <0.001). The BB genotype conferred a protective factor for papillary thyroid cancer (P <0.001, odds ratio (OR) 0.16; 95% confidence interval (CI) 0.06, 0.42), while the presence of the A allele appears to be a risk factor for papillary thyroid cancer (P <0.001, OR 3.54; 95% CI 1.86, 6.73). The intron 4 polymorphism of the NOS3 gene was associated with susceptibility to papillary thyroid cancer. Thus, future research into the effects of this polymorphism is essential.
Licença:: Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (
Appears in Collections:FCE-FAR - Artigos publicados em periódicos
PGCTS - Artigos publicados em periódicos

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