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Title: Use of galantamine in the treatment of Alzheimer's disease and strategies to optimize its biosynthesis using the in vitro culture technique
Authors: Santos, Gabriella Sousa
Sinoti, Simone Batista Pires
Almeida, Fabrício Tavares Cunha de
Silveira, Dâmaris
Simeoni, Luiz Alberto
Gomes-Copeland, Kicia Karinne Pereira
Assunto:: Alzheimer, Doença de
Amaryllidaceae
Biossíntese
Medicamentos
Cultivo in vitro
Issue Date: 2020
Publisher: Springer Nature
Citation: Santos, Gabriella Sousa et al. Use of galantamine in the treatment of Alzheimer's disease and strategies to optimize its biosynthesis using the in vitro culture technique. Plant Cell Tiss Organ Cult, v. 143, p. 13-29, 2020. DOI: https://doi.org/10.1007/s11240-020-01911-5.
Abstract: Galantamine is an alkaloid in the Amaryllidaceae family widely used in the treatment of Alzheimer's disease. Since its approval for clinical use in 2001, its effectiveness has been attested in numerous clinical trials. Due to the expressive and growing increase in Alzheimer's disease cases in the world, driven by the increase in life expectancy, the main risk factor for neurodegenerative diseases, demand for galantamine is expected to be intensified, this aggravating factor has encouraged researchers to seek viable alternatives for the commercialization of galantamine on a larger scale. However, due to its complex stereochemistry, the organic synthesis of galantamine proved to be a challenging task, thus constituting plants as its main source of production. In this sense, biotechnological techniques have emerged as an alternative and a more efficient means, since plants biosynthesize galantamine and other alkaloids without difficulty. This review summarizes the results of studies on the tools currently available in plant tissue culture capable of optimizing galantamine production aiming at large scale production for the treatment of Alzheimer's disease. Results of galantamine biosynthesis optimization from the use of biotic and abiotic elicitors, plants growth regulators, phytoregulator and precursors agents or intermediate components, endorse the clinical importance of galantamine in the treatment of Alzheimer's disease and the role of in vitro cultivation technique as an environmentally sustainable culture, are discussed.
DOI: https://doi.org/10.1007/s11240-020-01911-5
metadata.dc.relation.publisherversion: https://link.springer.com/article/10.1007/s11240-020-01911-5
Appears in Collections:FAR - Artigos publicados em periódicos

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