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Title: Molecular and cellular biomarkers of COVID-19 prognosis : protocol for the prospective cohort TARGET study
Authors: Kurizky, Patricia Shu
Nóbrega, Otávio T.
Soares, Alexandre Anderson de Sousa Munhoz
Aires, Rodrigo Barbosa
Albuquerque, Cleandro Pires de
Nicola, André Moraes
Andrade, Patrícia Albuquerque de
Carvalho, Andréa Teixeira
Naves, Luciana Ansaneli
Fontes, Wagner
Luz, Isabelle Souza
Felicori, Liza
Gomides, Ana Paulo Monteiro
Silva, Dayde Lane Mendonça
Espindola, Laila Salmen
Martins Filho, Olindo Assis
Lima, Sheila Maria Barbosa de
Mota, Licia Maria Henrique
Gomes, Ciro Martins
Assunto:: Covid-19
Sistema imunológico
Issue Date: 4-Mar-2021
Publisher: JMIR Publications
Citation: KURIZKY, Patricia et al. Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study. JMIR Research Protocols, v. 10, p. e24211, 2021. DOI: Disponível em: Acesso em: 14 abr. 2021.
Abstract: Background: Since the beginning of the COVID-19 pandemic, the world’s attention has been focused on better understanding the relation between the human host and the SARS-CoV-2 virus, as its action has led to hundreds of thousands of deaths. Objective: In this context, we decided to study certain consequences of the abundant cytokine release over the innate and adaptive immune systems, inflammation, and hemostasis, comparing mild and severe forms of COVID-19. Methods: To accomplish these aims, we will analyze demographic characteristics, biochemical tests, immune biomarkers, leukocyte phenotyping, immunoglobulin profile, hormonal release (cortisol and prolactin), gene expression, thromboelastometry, neutralizing antibodies, metabolic profile, and neutrophil function (reactive oxygen species production, neutrophil extracellular trap production, phagocytosis, migration, gene expression, and proteomics). A total of 200 reverse transcription polymerase chain reaction–confirmed patients will be enrolled and divided into two groups: mild/moderate or severe/critical forms of COVID-19. Blood samples will be collected at different times: at inclusion and after 9 and 18 days, with an additional 3-day sample for severe patients. We believe that this information will provide more knowledge for future studies that will provide more robust and useful clinical information that may allow for better decisions at the front lines of health care. Results: The recruitment began in June 2020 and is still in progress. It is expected to continue until February 2021. Data analysis is scheduled to start after all data have been collected. The coagulation study branch is complete and is already in the analysis phase.
Licença:: ©Patricia Kurizky, Otávio T Nóbrega, Alexandre Anderson De Sousa Munhoz Soares, Rodrigo Barbosa Aires, Cleandro Pires De Albuquerque, André Moraes Nicola, Patrícia Albuquerque, Andréa Teixeira-Carvalho, Luciana Ansaneli Naves, Wagner Fontes, Isabelle Souza Luz, Liza Felicori, Ana Paulo Monteiro Gomides, Dayde Lane Mendonça-Silva, Laila Salmen Espindola, Olindo Assis Martins-Filho, Sheila Maria Barbosa de Lima, Licia Maria Henrique Mota, Ciro Martins Gomes. Originally published in JMIR Research Protocols (, 04.03.2021. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on, as well as this copyright and license information must be included.
Appears in Collections:FAR - Artigos publicados em periódicos
FCE-FAR - Artigos publicados em periódicos
FMD - Artigos publicados em periódicos e preprints
UnB - Covid-19

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