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Title: Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
Authors: Caramelli, Bruno
Bernoche, Claudia Y.S.M. de
Sartori, Ana M.C
Spósito, Andrei Carvalho
Santos, Raul D.
Monachini, Maristela C.
Strabelli, Tania
Uip, Davi
Assunto:: Colesterol
HIV - infecção
Issue Date: Dec-2001
Citation: CARAMELLI, Bruno. Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate. Brazilian Journal of Infectious Diseases, Salvador, v. 5, n. 6, p. 332-338, dec. 2001. Disponível em: <>. Acesso em 15 mar. 2010.
Abstract: Hyperlipidemia has been frequently recorded as a side effect of treating HIV patients with protease inhibitors (PI). This study was initiated to analyze the modifications on blood lipids in HIV-patients receiving PI and the safety and efficacy of the treatment with fenofibrate. Total (TC) and HDL-cholesterol, triglycerides (TG), and CD4+ T-cell counts were measured in 30 HAART-naive patients (Group I) before and after PI introduction. In a second phase of the study, the effects of fenofibrate on lipids, CPK, CD4+, and viral load were determined in 13 patients (Group II) with elevated TC or TG. In Group I, 60% of the patients showed TC or TG elevations. Average increments of 31% and 146% in TC and TG respectively (p<0.0006 and p<0.0001) were observed. In Group II, fenofibrate treatment was associated with decrements of 6.6% (TC) and 45.7% (TG) (p=0.07 and 0.0002) and no modifications on CPK, CD4+, and viral load. In conclusion, hyperlipidemia is common during the treatment of HIV with protease inhibitors, and fenofibrate appears to be an effective and safe choice for its treatment.
Description: 7 f.
Appears in Collections:FMD - Artigos publicados em periódicos

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