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Title: Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)
Authors: McCullough, Peter A.
Alexander, Paul E.
Armstrong, Robin
Arvinte, Cristian
Bain, Alan F.
Bartlett, Richard P.
Berkowitz, Robert L.
Berry, Andrew C.
Borody, Thomas J.
Brewer, Joseph H.
Brufsky, Adam M.
Clarke, Teryn
Derwand, Roland
Eck, Alieta
Eck, John
Eisner, Richard A.
Fareed, George C.
Farella, Angelina
Fonseca, Silvia N. S.
Geyer Jr., Charles E.
Gonnering, Russell S.
Graves, Karladine E.
Gross, Kenneth B. V.
Hazan, Sabine
Held, Kristin S.
Hight, H. Thomas
Immanuel, Stella
Jacobs, Michael M.
Ladapo, Joseph A.
Lee, Lionel H.
Littell, John
Lozano, Ivette
Mangat, Harpal S.
McKinnon, John E.
Merritt, Lee D.
Orient, Jane M.
Oskoui, Ramin
Pompan, Donald C.
Procter, Brian C.
Prodromos, Chad
Rajter, Juliana Cepelowicz
Rajter, Jean-Jacques
Ram, C. Venkata S.
Rios, Salete da Silva
Risch, Harvey A.
Robb, Michael J. A.
Rutherford, Molly
Scholz, Martin
Singleton, Marilyn M.
Tumlin, James A.
Tyson, Brian M.
Urso, Richard G.
Victory, Kelly
Vliet, Elizabeth Lee
Wax, Craig M.
Wolkoff, Alexandre G.
Wooll, Vicki
Zelenko, Vladimir
Assunto:: SARS-CoV-2
Issue Date: 30-Dec-2020
Publisher: IMR Press
Citation: MCCULLOUGH, Peter A. et al. Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19). Reviews in Cardiovascular Medicine, v. 21, n. 4, p. 517-530, 2020. DOI: 10.31083/j.rcm.2020.04.264. Disponível em: Acesso em: 11 jan. 2021.
Abstract: The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death. Prompt early initiation of sequenced multidrug therapy (SMDT) is a widely and currently available solution to stem the tide of hospitalizations and death. A multipronged therapeutic approach includes 1) adjuvant nutraceuticals, 2) combination intracellular anti-infective therapy, 3) inhaled/oral corticosteroids, 4) antiplatelet agents/anticoagulants, 5) supportive care including supplemental oxygen, monitoring, and telemedicine. Randomized trials of individual, novel oral therapies have not delivered tools for physicians to combat the pandemic in practice. No single therapeutic option thus far has been entirely effective and therefore a combination is required at this time. An urgent immediate pivot from single drug to SMDT regimens should be employed as a critical strategy to deal with the large numbers of acute COVID-19 patients with the aim of reducing the intensity and duration of symptoms and avoiding hospitalization and death.
Licença:: This is an open access article under the CC BY 4.0 license (
DOI: 10.31083/j.rcm.2020.04.264
Appears in Collections:FMD - Artigos publicados em periódicos e preprints
UnB - Covid-19

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