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Title: Molecular and serological surveys of canine distemper virus : a meta-analysis of crosssectional studies
Authors: Costa, Vivaldo Gomes da
Saivish, Marielena Vogel
Rodrigues, Roger Luiz
Silva, Rebeca Francielle de Lima
Moreli, Marcos Lázaro
Krüger, Ricardo Henrique
metadata.dc.identifier.orcid: https://orcid.org/0000-0002-9359-0198
https://orcid.org/0000-0002-7627-621X
https://orcid.org/0000-0001-8042-4636
https://orcid.org/0000-0003-4637-211X
https://orcid.org/0000-0002-9599-361X
Assunto:: Cão - doenças
Cinomose canina
Morbillivírus
Issue Date: 29-May-2019
Publisher: PLoS ONE
Citation: COSTA, Vivaldo Gomes da et al. Molecular and serological surveys of canine distemper virus: a meta-analysis of cross-sectional studies. PLoS ONE, v. 14, n. 5, e0217594, 2019. DOI: https://doi.org/10.1371/journal.pone.0217594. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217594. Acesso em: 19 out. 2020.
Abstract: Background Canine morbillivirus (canine distemper virus, CDV) persists as a serious threat to the health of domestic dogs and wildlife. Although studies have been conducted on the frequency and risk factors associated with CDV infection, there are no comprehensive data on the current epidemiological magnitude in the domestic dog population at regional and national levels. Therefore, we conducted a cross-sectional study and included our results in a meta-analysis to summarize and combine available data on the frequency and potential risk factors associated with CDV infection. Methods For the cross-sectional study, biological samples from dogs suspected to have canine distemper (CD) were collected and screened for viral RNA. Briefly, the PRISMA protocol was used for the meta-analysis, and data analyses were performed using STATA IC 13.1 software. Results CDV RNA was detected in 34% (48/141) of dogs suspected to have CD. Following our meta-analysis, 53 studies were selected for a total of 11,527 dogs. Overall, the pooled frequency of CDV positivity based on molecular and serological results were 33% (95% CI: 23–43) and 46% (95% CI: 36–57), respectively. The pooled subgroup analyses of clinical signs, types of biological samples, diagnostic methods and dog lifestyle had a wide range of CDV positivity (range 8–75%). Free-ranging dogs (OR: 1.44, 95% CI: 1.05–1.97), dogs >24 months old (OR: 1.83, 95% CI: 1.1–3) and unvaccinated dogs (OR: 2.92, 95% CI: 1.26– 6.77) were found to be positively associated with CDV infection. In contrast, dogs <12 months old (OR: 0.36, 95% CI: 0.20–0.64) and dogs with a complete anti-CDV vaccination (OR: 0.18, 95% CI: 0.05–0.59) had a negative association. Conclusion Considering the high frequency of CDV positivity associated with almost all the variables analyzed in dogs, it is necessary to immediately and continuously plan mitigation strategies to reduce the CDV prevalence, especially in determined endemic localities.
Licença:: Copyright: © 2019 Costa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: https://doi.org/10.1371/journal.pone.0217594
Appears in Collections:CEL - Artigos publicados em periódicos

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