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Title: Adipocytes and macrophages interplay in the orchestration of tumor microenvironment : new implications in cancer progression
Authors: Corrêa, Luís Henrique
Corrêa, Rafael
Farinasso, Cecília Menezes
Dourado, Lívia Pimentel de Sant’Ana
Magalhães, Kelly Grace
Assunto:: Câncer
Obesidade
Inflamação
Tumores
Issue Date: 19-Sep-2017
Publisher: Frontiers
Citation: CORRÊA, Luís Henrique et al. Adipocytes and macrophages interplay in the orchestration of tumor microenvironment: new implications in cancer progression. Frontiers in Immunology, v. 8, art. 1129, 2017. DOI: https://doi.org/10.3389/fimmu.2017.01129. Disponível em: https://www.frontiersin.org/articles/10.3389/fimmu.2017.01129/full. Acesso em: 09 abr. 2020.
Abstract: Inflammation has been known as one of the main keys to the establishment and progression of cancers. Chronic low-grade inflammation is also a strategic condition that underlies the causes and development of metabolic syndrome and obesity. Moreover, obesity has been largely related to poor prognosis of tumors by modulating tumor microenvironment with secretion of several inflammatory mediators by tumor-associated adipocytes (TAAs), which can modulate and recruit tumor-associated macrophages. Thus, the understanding of cellular and molecular mechanisms that underlay and link inflammation, obesity, and cancer is crucial to identify potential targets that interfere with this important route. Knowledge about the exact role of each component of the tumor microenvironment is not yet fully understood, but the new insights in literature highlight the essential role of adipocytes and macrophages interplay as key factor to determine the fate of cancer progression. In this review article, we focus on the functions of adipocytes and macrophages orchestrating cellular and molecular mechanisms that lead to inflammatory modulation in tumor microenvironment, which will be crucial to cancer establishment. We also emphasized the mechanisms by which the tumor promotes itself by recruiting and polarizing macrophages, discussing the role of adipocytes in this process. In addition, we discuss here the newest possible anticancer therapeutic treatments aiming to retard the development of the tumor based on what is known about cancer, adipocyte, and macrophage polarization.
Licença:: © 2017 Corrêa, Corrêa, Farinasso, de Sant’Ana Dourado and Magalhães. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI: https://doi.org/10.3389/fimmu.2017.01129
Appears in Collections:CEL - Artigos publicados em periódicos

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