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Title: Overview of artemisinin effectiveness during outset years of its implementation in the western Brazilian Amazon
Authors: Pinto, Raquel de Medeiros
Sampaio, Vanderson de Souza
Melo, Gisely Cardoso de
Alecrim, Maria das Graças Costa
Mattos, Karine
Perdomo, Renata Trentin
Cordeiro, Sabrine da Costa
Parente, Ana Flávia Alves
Carvalho, Lídia Raquel de
Mendes, Rinaldo Pôncio
Lacerda, Marcus Vinícius Guimarães de
Monteiro, Wuelton Marcelo
Weber, Simone Schneider
metadata.dc.identifier.orcid: http://orcid.org/0000-0002-4181-142X
Assunto:: Plasmodium falciparum
Medicamentos
Malária - tratamento
Estudos de coorte
Malária
Issue Date: 2019
Publisher: Instituto Oswaldo Cruz, Ministério da Saúde
Citation: PINTO, Raquel de Medeiros et al. Overview of artemisinin effectiveness during outset years of its implementation in the western Brazilian Amazon. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, e190075, 2019. DOI: https://doi.org/10.1590/0074-02760190075. Disponível em: http://scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100320. Acesso em: 23 jan. 2020.
Abstract: BACKGROUND The elimination of malaria depends on the blocking of transmission and of an effective treatment. In Brazil, artemisinin therapy was introduced in 1991, and here we present a performance overview during implementation outset years. METHODS It is a retrospective cohort (1991 to 2002) of patients treated in a tertiary centre of Manaus, with positive microscopic diagnosis of Plasmodium falciparum malaria, under treatment with using injectable or rectal artemisinin derivatives, and followed over 35-days to evaluate parasite clearance, death and recurrence. FINDINGS This cohort outcome resulted 97.6% (1554/1593) of patients who completed the 35-day follow-up, 0.6% (10/1593) of death and 1.8% (29/1593) of follow-up loss. All patients that died and those that presented parasitaemia recurrence had pure P. falciparum infections and received monotherapy. Considering patients who completed 35-day treatment, 98.2% (1527/1554) presented asexual parasitaemia clearance until D4 and 1.8% (27/1554) between D5-D10. It is important to highlight that had no correlation between the five treatment schemes and the sexual parasite clearance. Finally, it is noteworthy that we were able to observe also gametocytes carriage during all follow-up (D0-D35). MAIN CONCLUSIONS Artemisinin derivatives remained effective in the treatment of falciparum malaria during first 12-years of use in north area of Brazil.
Licença:: (CC BY)
DOI: https://doi.org/10.1590/0074-02760190075
Appears in Collections:CEL - Artigos publicados em periódicos

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