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dc.contributor.authorCruz, Rossilene Conceição da Silvapt_BR
dc.contributor.authorBührer-Sékula, Samirapt_BR
dc.contributor.authorPenna, Gerson Oliveirapt_BR
dc.contributor.authorMoraes, Maria Elisabete Amaral dept_BR
dc.contributor.authorGonçalves, Heitor de Sápt_BR
dc.contributor.authorStefani, Mariane Martins de Araújopt_BR
dc.contributor.authorPenna, Maria Lúcia Fernandespt_BR
dc.contributor.authorPontes, Maria Araci de Andradept_BR
dc.contributor.authorTalhari, Sinésiopt_BR
dc.date.accessioned2019-01-02T13:52:47Z-
dc.date.available2019-01-02T13:52:47Z-
dc.date.issued2018pt_BR
dc.identifier.citationCRUZ, Rossilene Conceição da Silva et al. Clinical trial for uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): adverse effects approach. Anais Brasileiros de Dermatologia, Rio de Janeiro, v. 93, n. 3, p. 377-384, maio/jun. 2018. DOI: http://dx.doi.org/10.1590/abd1806-4841.20186709. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000300377&lng=en&nrm=iso. Acesso em: 12 abr. 2019.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/33503-
dc.language.isoenpt_BR
dc.publisherSociedade Brasileira de Dermatologiapt_BR
dc.rightsAcesso Abertopt_BR
dc.titleClinical trial for uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): adverse effects approachpt_BR
dc.typeArtigopt_BR
dc.subject.keywordDrogaspt_BR
dc.subject.keywordHanseníasept_BR
dc.subject.keywordTerapêuticapt_BR
dc.rights.licenseAnais Brasileiros de Dermatologia - (CC BY NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License which permits unrestricted noncommercial use, distribution, and reproduction in any medium provided the original work is properly cited. Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000300377&lng=en&nrm=iso. Acesso em: 12 abr. 2019.-
dc.identifier.doihttp://dx.doi.org/10.1590/abd1806-4841.20186709pt_BR
dc.description.abstract1BACKGROUND: The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR), designed to evaluate the effectiveness of a six-months regimen, assessed the adverse effects caused by the drugs. OBJECTIVE: Describe adverse effects due to MDT in U-MDT/CT-BR, comparing the uniform regimen (U-MDT) to the current WHO regimen (R-MDT). Patients and methods: After operational classification, patients were randomly allocated to the study groups. U-MDT PB and U-MDT MB groups, received the U-MDT regimen, six doses of MB-MDT (rifampicin, dapsone and clofazimine). R-MDT PB and R-MDT MB groups, received the WHO regimens: six doses (rifampicin and dapsone) for PB and 12 doses (rifampicin, dapsone and clofazimine) for MB. During treatment, patients returned monthly for clinical and laboratorial evaluation. Patients with single lesion were not included in this trial. RESULTS: Skin pigmentation (21.7%) and xerosis (16.9%) were the most frequent complaints among 753 patients. Laboratory exams showed hemoglobin concentration lower than 10g/dL in 23.3% of the patients, glutamic oxaloacetic transaminase (GOT) above 40U/L in 29.5% and glutamic pyruvic transaminase (GPT) above 40U/L in 28.5%. Twenty-four patients (3.2%) stopped dapsone intake due to adverse effects, of whom 16.6% due to severe anemia. One case of sulfone syndrome was reported. STUDY LIMITATIONS: Loss of some monthly laboratory sample collection. CONCLUSIONS: There was no statistical difference regarding adverse effects in the R-MDT and U-MDT groups but anemia was greater in patients from R-MDT/MB group, therefore adverse effects do not represent a constraint to recommend the six-month uniform regimen of treatment for all leprosy patients.-
dc.description.unidadeFaculdade de Medicina (FM)-
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