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Title: Effects of disturbed blood flow during exercise on endothelial function : a time course analysis
Authors: Paiva, Flávio Macedo Lahud
Vianna, Lauro Casqueiro
Fernandes, I. A.
Nóbrega, A. C.
Lima, Ricardo Moreno
Assunto:: Restrição do fluxo sanguíneo
Dilatação fluxo-mediada
Estresse de cisalhamento
Issue Date: 2016
Publisher: Associação Brasileira de Divulgação Científica
Citation: PAIVA, F. M. et al. Effects of disturbed blood flow during exercise on endothelial function: a time course analysis. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 49, n. 4, e5100, 2016. Disponível em: <>. Acesso em: 12 mar. 2018. Epub Feb 23, 2016. doi:
Abstract: This study aimed to examine the time course of endothelial function after a single handgrip exercise session combined with blood flow restriction in healthy young men. Nine participants (28±5.8 years) completed a single session of bilateral dynamic handgrip exercise (20 min with 60% of the maximum voluntary contraction). To induce blood flow restriction, a cuff was placed 2 cm below the antecubital fossa in the experimental arm. This cuff was inflated to 80 mmHg before initiation of exercise and maintained through the duration of the protocol. The experimental arm and control arm were randomly selected for all subjects. Brachial artery flow-mediated dilation (FMD) and blood flow velocity profiles were assessed using Doppler ultrasonography before initiation of the exercise, and at 15 and 60 min after its cessation. Blood flow velocity profiles were also assessed during exercise. There was a significant increase in FMD 15 min after exercise in the control arm compared with before exercise (64.09%±16.59%, P=0.001), but there was no change in the experimental arm (-12.48%±12.64%, P=0.252). FMD values at 15 min post-exercise were significantly higher for the control arm in comparison to the experimental arm (P=0.004). FMD returned to near baseline values at 60 min after exercise, with no significant difference between arms (P=0.424). A single handgrip exercise bout provoked an acute increase in FMD 15 min after exercise, returning to near baseline values at 60 min. This response was blunted by the addition of an inflated pneumatic cuff to the exercising arm.
Licença:: Brazilian Journal of Medical and Biological Research - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Fonte: Acesso em: 12 mar. 2018.
Appears in Collections:FEF - Artigos publicados em periódicos

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