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Title: Catalyzed and non-catalyzed synthesis of bioactive monastrol
Authors: Alvim, Haline Gerica de Oliveira
Corrêa, José Raimundo
Machado, Taynara Rezende
Silva, Wender Alves da
Neto, Brenno A.
Assunto:: Monastrol
Reação de Biginelli
Issue Date: 2014
Publisher: Sociedade Brasileira de Química
Citation: ALVIM, Haline Gerica de Oliveira et al. Catalyzed and non-catalyzed synthesis of bioactive monastrol. Química Nova, São Paulo, v. 37, n. 10, p. 1713-1715, 2014. DOI: Disponível em: Acesso em: 20 jul. 2020.
Abstract: The bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions. The use of two Lewis acids (FeCl3 and CuCl2) and two Brønsted acids (HCl and CF3COOH) as catalysts improved the reaction yields of the transformation compared with the non-catalyzed reaction. The experiments investigated catalysis and its role, the importance of multicomponent reactions and their green features, and the application of these concepts to the synthesis of a biologically important structure.
Licença:: Química Nova - (CC BY-NC) - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Fonte: m=iso&tlng=en. Acesso em: 20 jul. 2020.
Appears in Collections:IQ - Artigos publicados em periódicos

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