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Title: Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl / 6 mice
Authors: Santarem, Ana Angélica Amorim
Greggianin, Gabriel Frizon
Debastiani, Rafaela Garcia
Ribeiro, Jefferson Bruno Pereira
Polli, Demerson Andre
Sampaio, Raimunda Nonata Ribeiro
Assunto:: Leishmaniose cutânea
Pentoxifilina
Miltefosina
Issue Date: Aug-2014
Publisher: Sociedade Brasileira de Medicina Tropical - SBMT
Citation: SANTAREM, Ana Angélica Amorim et al. Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl / 6 mice. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba, v. 47, n. 4, p. 517-520, jul./ago. 2014. DOI: https://doi.org/10.1590/0037-8682-0202-2013. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000400517&lng=en&tlng=en. Acesso em: 27 jul. 2020.
Abstract: Introduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxifylline (8mg/kg/day), and untreated. Response to treatment was evaluated using paw diameter and parasitological criteria. Results The number of viable Leishmania reduced significantly within the miltefosine-pentoxifylline group (p < 0.05). Conclusions There is hope that a viable treatment exists for Leishmania infection.
Licença:: Revista da Sociedade Brasileira de Medicina Tropical - (CC BY-NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000400517&lng=en&tln g=en. Acesso em: 27 jul. 2020.
DOI: https://dx.doi.org/10.1590/0037-8682-0202-2013
Appears in Collections:FMD - Artigos publicados em periódicos e preprints

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