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Title: Biological and structure-activity evaluation of chalcone derivatives against bacteria and fungi
Authors: Silva, Wender A.
Andrade, Carlos Kleber Z.
Napolitano, Hamilton B.
Vencato, Ivo
Lariucci, Carlito
Castro, Miriam. R. C. de
Camargo, Ademir J.
Assunto:: chalcones
biological activities
X-ray structures
theoretical calculations
Issue Date: 2013
Publisher: Sociedade Brasileira de Química
Citation: J. Braz. Chem. Soc.,v.24,n.1,p.133-144,2013
Abstract: The present work describes the antibacterial and antifungal activities of several chalcones obtained by a straight Claisen-Schmidt aldol condensation determined by the minimal inhibitory concentration against different microorganisms (Gram-positive and Gram-negative bacteria and fungi). Solid state crystal structures of seven chalcones were determined by X-ray diffraction (XRD) analysis. Chemometric studies were carried out in order to identify a potential structure-activity relationship.
O presente trabalho descreve as atividades antibacterianas e antifúngicas de diversas chalconas obtidas diretamente através da condensação aldólica tipo Claisen-Schmidt das quais se determinou a concentração inibitória mínima frente a diferentes microrganismos (bactérias Gram-positivas e Gram-negativas e fungos). Estruturas no estado sólido cristalino de sete chalconas foram determinadas por análise de difração de raios X (XRD). Estudos quimiométricos foram realizados com intuito de identificar uma potencial relação entre estrutura e atividade.
DOI: https://dx.doi.org/10.1590/S0103-50532013000100018
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