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Title: Prevalence of human papillomavirus type 16 variants in the Federal District, Central Brazil
Authors: Cruz, Márcio R
Cerqueira, Daniela M
Cruz, Waldenor B
Camara, Geni NL
Brígido, Marcelo de Macedo
Silva, Evandro O
Carvalho, Luciano GS
Martins, Cláudia RF
Assunto:: human papillomavirus type 16
Federal District
Issue Date: 2004
Publisher: Instituto Oswaldo Cruz, Ministério da Saúde
Citation: Mem. Inst. Oswaldo Cruz,v.99,n.3,p.281-282,2004
Abstract: We report the prevalence of human papillomavirus type 16 (HPV-16) variants in women with cervical lesions from the Federal District, Central Brazil. We analyzed 34 HPV-16 samples, identifying the sequence variations of E6 and L1 genes and correlating variant frequency with disease status. The most prevalent HPV-16 variant was the European (50%), followed by Asian-American (41.2%), African-1 (5.9%), and African-2 (2.9%). European and non-European variants appeared in equal frequencies among the cytological types of lesions - atypical squamous or glandular cells of undetermined significance, cytological alterations suggesting HPV infection, cervical intraepithelial neoplasias, squamous cell carcinoma, and adenocarcinoma.
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