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dc.contributor.authorSantana, A.N.C.pt_BR
dc.contributor.authorLeite, A.B.pt_BR
dc.contributor.authorFrança, M.S.F.pt_BR
dc.contributor.authorFrança, L.pt_BR
dc.contributor.authorVale, O.C.pt_BR
dc.contributor.authorCunha, R.B.pt_BR
dc.contributor.authorRicart, C.A.O.pt_BR
dc.contributor.authorSousa, M.V.pt_BR
dc.contributor.authorCarvalho, K.M.pt_BR
dc.date.accessioned2017-12-07T04:28:30Z-
dc.date.available2017-12-07T04:28:30Z-
dc.date.issued1998pt_BR
dc.identifier.citationBraz J Med Biol Res,v.31,n.10,p.1335-1338,1998pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/25456-
dc.description.abstractA neurotoxic peptide, granulitoxin (GRX), was isolated from the sea anemone Bunodosoma granulifera. The N-terminal amino acid sequence of GRX is AKTGILDSDGPTVAGNSLSGT and its molecular mass is 4958 Da by electrospray mass spectrometry. This sequence presents a partial degree of homology with other toxins from sea anemones such as Bunodosoma caissarum, Anthopleura fuscoviridis and Anemonia sulcata. However, important differences were found: the first six amino acids of the sequence are different, Arg-14 was replaced by Ala and no cysteine residues were present in the partial sequence, while two cysteine residues were present in the first 21 amino acids of other toxins described above. Purified GRX injected ip (800 µg/kg) into mice produced severe neurotoxic effects such as circular movements, aggressive behavior, dyspnea, tonic-clonic convulsion and death. The 2-h LD50 of GRX was 400 ± 83 µg/kg.pt_BR
dc.language.isoenpt_BR
dc.publisherAssociação Brasileira de Divulgação Científicapt_BR
dc.rightsAcesso Abertopt_BR
dc.titlePartial sequence and toxic effects of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granuliferapt_BR
dc.typeArtigopt_BR
dc.subject.keywordBunodosoma granuliferapt_BR
dc.subject.keywordsea anemonespt_BR
dc.subject.keywordPeptídeos tóxicospt_BR
dc.identifier.doihttps://dx.doi.org/10.1590/S0100-879X1998001000015pt_BR
dc.description.unidadeEm processamento-
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