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dc.contributor.authorSousa, Isabel Garcia-
dc.contributor.authorAlmo, Manuela Maragno do-
dc.contributor.authorSimi, Kelly Cristina Rodrigues-
dc.contributor.authorBezerra, Maryani Andressa Gomes-
dc.contributor.authorAndrade, Rosângela Vieira-
dc.contributor.authorMaranhão, Andréa Queiroz-
dc.contributor.authorBrígido, Marcelo de Macedo-
dc.date.accessioned2017-07-25T17:21:35Z-
dc.date.available2017-07-25T17:21:35Z-
dc.date.issued2017-03-14-
dc.identifier.citationSOUSA, Isabel Garcia et al. MicroRNA expression profiles in human CD3+ T cells following stimulation with anti‑human CD3 antibodies. BMC Res Notes, v. 10, Article 124, 14 mar. 2017. Disponível em: <https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-017-2442-y>. Acesso em: 27 jun. 2017. doi: https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-017-2442-y.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/23881-
dc.language.isoInglêspt_BR
dc.publisherBioMed Centralpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleMicroRNA expression profiles in human CD3+ T cells following stimulation with anti‑human CD3 antibodiespt_BR
dc.typeArtigopt_BR
dc.subject.keywordAnticorpospt_BR
dc.subject.keywordImunologiapt_BR
dc.rights.license© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.pt_BR
dc.identifier.doihttps://dx.doi.org/10.1186/s13104-017-2442-ypt_BR
dc.description.abstract1Background: Anti-CD3 therapy can induce immunosuppression by several non mutually exclusive mechanisms that have been proposed to explain the therapeutic effect the administration anti-CD3 mAb, but its immunoregulatory mechanism is still not completely clear. In T cells, microRNAs (miRNAs) regulate several pathways, including those associated with immune tolerance. Here, we report changes in miRNA expression in T cells following treatment with anti-human CD3 antibodies. Peripheral blood mononuclear cells were cultured in the presence of the monoclonal antibody OKT3 or a recombinant fragment of humanized anti-CD3. Following these treatments, the expression profiles of 31 miRNA species were assessed in T cells using TaqMan arrays. Results: Eight of the tested miRNAs (miR-155, miR-21, miR-146a, miR-210, miR-17, miR-590-5p, miR-106b and miR- 301a) were statistically significantly up- or down-regulated relative to untreated cells. Conclusions: Stimulation of T cells with anti-human CD3 antibodies alters miRNA expression patterns, including of miRNA species associated with immune regulatory pathways.pt_BR
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