Skip navigation
Please use this identifier to cite or link to this item: https://repositorio.unb.br/handle/10482/20273
Files in This Item:
File Description SizeFormat 
ARTIGO_ExperimentalInfectionLeishmania.pdf582,31 kBAdobe PDFView/Open
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCuba, César Augusto Cuba-
dc.contributor.authorFerreira, Vera-
dc.contributor.authorBampi, Maria-
dc.contributor.authorMagalhães, Albino Verçosa de-
dc.contributor.authorMarsden, Philip Davis-
dc.contributor.authorVexenat, Alejandro-
dc.contributor.authorMello, Milton Thiago de-
dc.date.accessioned2016-05-17T12:40:12Z-
dc.date.available2016-05-17T12:40:12Z-
dc.date.issued1990-10-
dc.identifier.citationCUBA, César A. Cuba et al. Experimental infection with Leishmania (Viannia) braziliensis, and Leishmania (Leishmania) amazonensis in the marmoset, Callithrix penicillata (Primates: Callithricidae). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 85, n. 4, p. 459-467, out./dez. 1990. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000400011&lng=en&nrm=iso>. Acesso em: 16 maio 2016. http://dx.doi.org/10.1590/S0074-02761990000400011.en
dc.identifier.urihttp://repositorio.unb.br/handle/10482/20273-
dc.description.abstractFoureen marmosets (Callithrix penicillata) were inoculated intradermally with promastigotes and/or amastigotes of Leishmania (Viannia) brazilensis (L. (V) b.) strains MHOM/BR/83/LTB-300MHOM/BR/85/LTB-12 MHOM/BR/81/LTB-179 and MHOM/BR/82/LTB-250. The evolution of subsequent lesions was studied for 15 to 75 weeks post-inoculation (PI). All but of the L. (V) b. injected marmosets developed a cutaneous lesion at the point of inoculation after 3 to 9 weeks, characterized by the appearance of subcutaneous nodules containing parasites. parasites were isolated by culture (Difco Blood Agar) from all 11 positive animals. The maximum size of the lesions was variable and ranged between 37 mm² to 107 mm². Ulceration of primary nodules became evident after 3 to 12 weeks in all infected marmosets, but was faster and larger in 5 of the 11 animals. The active lesions persisted in 9 out of 11 Callithrix until the en of the observation period, which varied from 15-75 weeks. In 3 animals spontaneous healing of their lesions (13 to 25 weeks, PI) was observed buth with cryptic parasitism. In another 2 infected animals there was regression followed by reactivation of the cutaneous lesions. The appearance of smaller satellite lesions adjacent to primary ones, as well as metastatic lesions to the ear lobes, were documented in 2 animals. Promastigotes of L. (Leishmania) amazonensis (L.(L)a.) MHOM/BR/77/LTB-16 were inoculated in 1 marmoset. This animal remained chronically infected for 6 months and the lesions developed in a similar manner to L.(V)b. infected marmosets. No significant differences in clinical and parasitological behaviour were observed between promastigote or amastigote derived infections of the 2 species. Both produced chronic, long lasting lesions which eventually healed. The same was true for parameters of size and ulceration. Skin tests converted to parasite in 11 of 15 inected masmosets and in 10 of 12 parasite positive animnals. Moderate levels of circulating antibodies were also observed by IFAT /IgG assays. In spite of the failure to reproduce the mucosal form of the disease, an important aspect of the Callithrix model in experimental cutaneous leishmaniasis lies in the reproduction of 2 clinical events that are common in humans, namely, the chronic ulceration and spontaneous healing of the lesions.en
dc.language.isoInglêsen
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúdeen
dc.rightsAcesso Abertoen
dc.titleExperimental infection with Leishmania (Viannia) braziliensis, and Leishmania (Leishmania) amazonensis in the marmoset, Callithrix penicillata (Primates: Callithricidae)en
dc.typeArtigoen
dc.subject.keywordLeishmaniaen
dc.subject.keywordSaguien
dc.rights.licenseInstituto Oswaldo Cruz, Ministério da Saúde - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons (Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000400011&lng=en&nrm=iso. Acesso em: 15 abr. 2016.en
dc.identifier.doihttp://dx.doi.org/10.1590/S0074-02761990000400011en
Appears in Collections:FMD - Artigos publicados em periódicos e preprints
UnB - Professores Eméritos

Show simple item record Recommend this item " class="statisticsLink btn btn-primary" href="/handle/10482/20273/statistics">



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.