|ARTIGO_IdealizedPPATherapies.pdf||543,07 kB||Adobe PDF||View/Open|
|Title:||Idealized PPARγ-based therapies : lessons from bench and bedside|
|Authors:||Amato, Angélica Amorim|
Neves, Francisco de Assis Rocha
|Assunto::||Resistência à insulina|
Medicamentos - uso terapêutico
|Publisher:||Hindawi Publishing Corporation|
|Citation:||AMATO, Angélica Amorim; NEVES, Francisco de Assis Rocha. Idealized PPARγ-based therapies: lessons from bench and bedside. PPAR RES, v. 2012, p.1-9, 2012. Disponível em: <http://www.hindawi.com/journals/ppar/2012/978687/>. Acesso em: 17 maio 2013.|
The incidence of type 2 (T2D) diabetes and other chronic conditions associated with insulin resistance is increasing at an alarming rate, underscoring the need for effective and safe therapeutic strategies. Peroxisome-proliferator-activated receptor gamma (PPARγ) has emerged as a critical regulator of glucose homeostasis, lipid homeostasis, and vascular inflammation. Currently marketed drugs targeting this receptor, the thiazolidinediones (TZDs), have proven benefits on insulin resistance and hyperglycemia associated with T2D. Unfortunately, they have been associated with long-term unfavorable effects on health, such as weight gain, plasma volume expansion, bone loss, cardiovascular toxicity, and possibly cancer, and these safety concerns have led to reduced interest for many PPARγ ligands. However, over the last years, data from human genetic studies, animal models, and studies with ligands have increased our understanding of PPARγ’s actions and provided important insights into how ligand development strategies could be optimized to increase effectiveness and safety of PPARγ-based therapies.
|Licença::||Copyright © 2012 A. A. Amato and F. de Assis Rocha Neves. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: http://www.hindawi.com/journals/ppar/2012/978687/|
|Appears in Collections:||FAR - Artigos publicados em periódicos|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.