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Title: Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells
Authors: Felipe, Maria Sueli Soares
Andrade, Rosângela Vieira de
Arraes, Fabrício Barbosa Monteiro
Nicola, André Moraes
Maranhão, Andréa Queiroz
Torres, Fernando Araripe Gonçalves
Pereira, Ildinete Silva
Fonseca, Márcio José Poças
Campos, Élida Geralda
Moraes, Lídia Maria Pepe de
Andrade, Patrícia Albuquerque de
Tavares, Aldo Henrique Fonseca Pacheco
Silva, Simoneide Souza
Kyaw, Cynthia Maria
Souza, Diorge Paulo
PbGenome Network
Pereira, Maristela
Jesuíno, Rosália Santos Amorim
Andrade, Edmar Vaz de
Parente, Juliana Alves
Oliveira, Gisele Silva de
Barbosa, Mônica Santiago
Martins, Natália Florêncio
Fachin, Ana Lúcia
Cardoso, Renato Sousa
Passos Júnior, Geraldo Aleixo da Silva
Almeida Júnior, Nalvo Franco de
Walter, Maria Emília Machado Telles
Soares, Célia Maria de Almeida
Carvalho, Maria José Albuquerque de
Brígido, Marcelo de Macedo
Assunto:: Paracoccidioides brasiliensis
Fungos patogênicos
Micologia
Issue Date: Jul-2005
Publisher: Sociedade Americana de Bioquímica e Biologia Molecular
Citation: FELIPE, Maria Sueli Soares et al. Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells. The Journal Of Biological Chemistry, Rockville, v. 280, n. 26, Issue of July 1, p. 24706–24714, 2005. Disponível em: <http://www.jbc.org/content/280/26/24706.full.pdf>. Acesso em: 07 mar. 2013. DOI 10.1074/jbc.M500625200
Abstract: Paracoccidioides brasiliensis is the causative agent of paracoccidioidomycosis, a disease that affects 10 million individuals in Latin America. This report depicts the results of the analysis of 6,022 assembled groups from mycelium and yeast phase expressed sequence tags, covering about 80% of the estimated genome of this dimorphic, thermo-regulated fungus. The data provide a comprehensive view of the fungal metabolism, including overexpressed transcripts, stage-specific genes, and also those that are up- or down-regulated as assessed by in silico electronic subtraction and cDNA microarrays. Also, a significant differential expression pattern in mycelium and yeast cells was detected, which was confirmed by Northern blot analysis, providing insights into differential metabolic adaptations. The overall transcriptome analysis provided information about sequences related to the cell cycle, stress response, drug resistance, and signal transduction pathways of the pathogen. Novel P. brasiliensis genes have been identified, probably corresponding to proteins that should be addressed as virulence factor candidates and potential new drug targets.
Description: This work was supported by MCT, CNPq, CAPES, FUB, UFG, and FUNDECT-MS. PbGenome Network: Alda Maria T. Ferreira, Alessandra Dantas, Alessandra J. Baptista, Alexandre M. Bailão, Ana Lídia Bonato, André C. Amaral, Bruno S. Daher, Camila M. Silva, Christiane S. Costa, Clayton L. Borges, Cléber O. Soares, Cristina M. Junta, Daniel A. S. Anjos, Edans F. O. Sandes, Eduardo A. Donadi, Elza T. Sakamoto-Hojo, Flábio R. Araújo, Flávia C. Albuquerque, Gina C. Oliveira, João Ricardo M. Almeida, Juliana C. Oliveira, Kláudia G. Jorge, Larissa Fernandes, Lorena S. Derengowski, Luís Artur M. Bataus, Marcus A. M. Araújo, Marcus K. Inoue, Marlene T. De-Souza, Mauro F. Almeida, Nádia S. Parachin, Nadya S. Castro, Odair P. Martins, Patrícia L. N. Costa, Paula Sandrin-Garcia, Renata B. A. Soares, Stephano S. Mello, and Viviane C. B. Reis
Licença:: Permitido copiar, distribuir, transmitir e adaptar a obra - sem nenhum custo e sem permissão - para uso não comercial, desde que citada a fonte original. "This research was originally published in The Journal of Biological Chemistry. Maria Sueli S. Felipe, Rosângela V. Andrade, Fabrício B. M. Arraes, André M. Nicola, Andrea Q. Maranhão, Fernando A. G. Torres, Ildinete Silva-Pereira, Márcio J. Poças-Fonseca, Élida G. Campos,a Lídia M. P. Moraes,a Patrícia A. Andrade,Aldo H. F. P. Tavares, Simoneide S. Silva, Cynthia M. Kyaw,a Diorge P. Souza,PbGenome Network, Maristela Pereira,a Rosália S. A. Jesuíno, Edmar V. Andrade,Juliana A. Parente, Gisele S. Oliveira, Mônica S. Barbosa, Natália F. Martins, Ana L. Fachin, Renato S. Cardoso, Geraldo A. S. Passos, Nalvo F. Almeida, Maria Emília M. T. Walter,Célia M. A. Soares,Maria José A. Carvalho and Marcelo M. Brígido. Transcriptional Profiles of the Human Pathogenic Fungus Paracoccidioides brasiliensis in Mycelium and Yeast Cells. The Journal of Biological Chemistry. 2005, Vol. 280, No. 26, Issue of July 1, pp. 24706–24714. © Sociedade Americana de Bioquímica e Biologia Molecular." Fonte: http://www.jbc.org/site/misc/Copyright_Permission.xhtml. Acesso em: 07 mar. 2013.
DOI: DOI https://dx.doi.org/10.1074/jbc.M500625200
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CIC - Artigos publicados em periódicos
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