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Title: The higher exercise intensity and the presence of allele I of ACE gene elicit a higher post-exercise blood pressure reduction and nitric oxide release in elderly women : an experimental study
Authors: Santana, Hugo Alexandre de Paula
Moreira, Sérgio Rodrigues
Botelho Neto, Willson
Silva, Carla Britto da
Sales, Marcelo Magalhães de
Oliveira, Vanessa N.
Asano, Ricardo Yukio
Espíndola, Foued Salmen
Nóbrega, Otávio de Tolêdo
Campbell, Carmen Silvia Grubert
Simões, Herbert Gustavo
Assunto:: Exercícios físicos
Mulheres idosas
Pressão arterial
Issue Date: 2011
Publisher: BioMed Central
Citation: SANTANA, Hugo Alexndre de Paula et al. The higher exercise intensity and the presence of allele i of ace gene elicit a higher post-exercise blood pressure reduction and nitric oxide release in elderly women: an experimental study. BMC Cardiovascular Disorders, v. 11, n. 71, p. 3-8, 2011. Disponível em:<>. Acesso em: 30 nov. 2012.
Abstract: Background The absence of the I allele of the angiotensin converting enzyme (ACE) gene has been associated with higher levels of circulating ACE, lower nitric oxide (NO) release and hypertension. The purposes of this study were to analyze the post-exercise salivary nitrite (NO2-) and blood pressure (BP) responses to different exercise intensities in elderly women divided according to their ACE genotype. Methods Participants (n = 30; II/ID = 20 and DD = 10) underwent three experimental sessions: incremental test - IT (15 watts workload increase/3 min) until exhaustion; 20 min exercise 90% anaerobic threshold (90% AT); and 20 min control session without exercise. Volunteers had their BP and NO2- measured before and after experimental sessions. Results Despite both intensities showed protective effect on preventing the increase of BP during post-exercise recovery compared to control, post-exercise hypotension and increased NO2- release was observed only for carriers of the I allele (p < 0.05). Conclusion Genotypes of the ACE gene may exert a role in post-exercise NO release and BP response.
Licença:: BMC Cardiovascular Disorders - Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons (Attribution 2.0 Generic (CC BY 2.0)). Fonte: Acesso em: 30 nov. 2012.
Appears in Collections:FCE-SC - Artigos publicados em periódicos

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