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Title: Association of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women
Authors: Lins, Tulio Cesar de Lima
Pires, Alause da Silva
Paula, Roberta da Silva
Moraes, Clayton Franco
Vieira, Rodrigo G.
Vianna, Lucy Gomes
Nóbrega, Otávio de Tolêdo
Pereira, Rinaldo Wellerson
Assunto:: Mulheres - nutrição
Mulheres idosas
Obesidade em mulheres
Genética de populações
Mulheres - saúde e higiene
Issue Date: 2012
Publisher: Sociedade Brasileira de Genética
Citation: LINS, Tulio C. et al. Association of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women. Genetics and Molecular Biology, São Paulo, v. 35, n. 3, 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000400005&lng=pt&nrm=iso>. Acesso em: 27 nov. 2012. http://dx.doi.org/10.1590/S1415-47572012005000047.
Abstract: The prevalence of metabolic disorders varies among ethnic populations and these disorders represent a critical health care issue for elderly women. This study investigated the correlation between genetic ancestry and body composition, metabolic traits and clinical status in a sample of elderly women. Clinical, nutritional and anthropometric data were collected from 176 volunteers. Genetic ancestry was estimated using 23 ancestry-informative markers. Pearsons correlation test was used to examine the relationship between continuous variables and an independent samples t-test was used to compare the means of continuous traits within categorical variables. Overall ancestry was a combination of European (57.49%), Native American (25.78%) and African (16.73%). Significant correlations were found for European ancestry with body mass index (r = 0.165; p = 0.037) and obesity (mean difference (MD) = 5.3%; p = 0.042). African ancestry showed a significant correlation with LDL (r = 0.159, p = 0.035), VLDL (r = -0.185; p = 0.014), hypertriglyceridemia (MD = 6.4%; p = 0.003) and hyperlipidemia (MD = 4.8%; p = 0.026). Amerindian ancestry showed a significant correlation with triglyceride levels (r = 0.150; p = 0.047) and hypertriglyceridemia (MD = 4.5%; p = 0.039). These findings suggest that genetic admixture may influence the etiology of lipid metabolism-related diseases and obesity in elderly women.
Licença:: Genetics and Molecular Biology - Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons (Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0 ). Fonte: http://www.scielo.br/scielo.php?script=sci_serial&pid=1415-4757&lng=pt&nrm=iso. Acesso em: 27 nov. 2012.
DOI: http://dx.doi.org/10.1590/S1415-47572012005000047
Appears in Collections:FCE-SC - Artigos publicados em periódicos

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