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Title: Antileishmanial and trypanocidal activity of brazilian Cerrado plants
Authors: Mesquita, Mariana Laundry de
Desrivot, Julie
Bories, Christian
Fournet, Alain
Paula, José Elias de
Grellier, Philippe
Espindola, Laila Salmen
Assunto:: Leishmaniose
Chagas, Doença de
Tripanossoma cruzi
Plantas - Cerrados
Issue Date: Nov-2005
Publisher: Instituto Oswaldo Cruz, Ministério da Saúde
Citation: MESQUITA, Mariana Laundry de. Antileishmanial and trypanocidal activity of Brazilian cerrado plants. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 7, nov. 2005. Disponível em: <>. Acesso em: 11 maio 2012.
Abstract: The side effects and the emerging resistance to the available drugs against leishmaniasis and trypanosomiasis led to the urgent need for new therapeutic agents against these diseases. Thirty one extracts of thirteen medicinal plants from the Brazilian Cerrado were therefore evaluated in vitro for their antiprotozoal activity against promastigotes of Leishmania donovani, and amastigotes of Trypanosoma cruzi. Among the selected plants, Casearia sylvestris var. lingua was the most active against both L. donovani and T. cruzi. Fifteen extracts were active against promastigotes of L. donovani with concentrations inhibiting 50% of parasite growth (IC50) between 0.1-10 µg/ml, particularly those of Annona crassiflora (Annonaceae), Himatanthus obovatus (Apocynaceae), Guarea kunthiana (Meliaceae), Cupania vernalis (Sapindaceae), and Serjania lethalis (Sapindaceae). With regard to amastigotes of T. cruzi, extracts of A. crassiflora, Duguetia furfuracea (Annonaceae), and C. sylvestris var. lingua were active with IC50 values between 0.3-10 µg/ml. Bioassay fractionations of the more active extracts are under progress to identify the active antiparasite compounds.
Licença:: Memórias do Instituto Oswaldo Cruz - Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons (Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)). Fonte: Acesso em: 11 maio 2012.
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