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dc.contributor.authorZacca, Jorge Jardim-
dc.contributor.authorGiudice, Gabriella Hamú-
dc.contributor.authorSouza, Mônica P.-
dc.contributor.authorCaldas, Luíza N. B.-
dc.contributor.authorVieira, Maurício L.-
dc.contributor.authorMachado, Ângelo Henirque de Lira-
dc.date.accessioned2024-02-15T15:18:49Z-
dc.date.available2024-02-15T15:18:49Z-
dc.date.issued2021-
dc.identifier.citationZACCA, Jorge J. et al. Development and validation of analytical method for identification of new psychoactive substances using linear retention indexes and gas chromatography-mass spectrometry. Journal of Chromatography A, [S. l.], v. 1636, 461783, 11 jan. 2021. DOI: https://doi.org/10.1016/j.chroma.2020.461783pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/47742-
dc.language.isoengpt_BR
dc.publisherElsevier B.V.pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleDevelopment and validation of analytical method for identification of new psychoactive substances using linear retention indexes and gas chromatography-mass spectrometrypt_BR
dc.typeArtigopt_BR
dc.subject.keywordCromatografia gasosapt_BR
dc.subject.keywordEspectrometria de massapt_BR
dc.subject.keywordSubstâncias psicoativaspt_BR
dc.identifier.doihttps://doi.org/10.1016/j.chroma.2020.461783pt_BR
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0021967320310578?via%3Dihubpt_BR
dc.description.abstract1New Psychoactive Substances (NPS) are quickly developing to evade legislation, posing unprecedented challenges to public health and law enforcement authorities around the world. The aim of this work was to develop and validate a simple and reliable non-target gas chromatography/mass spectrometry (GC/MS) analytical method based on linear retention indexes for the expeditious identification of NPS without the need of analytical standards. The method was optimized and validated for 22 different drugs covering ten categories: phenethylamines (amphetamine, MDMA, methamphetamine, 25C–NBOMe, 2-FA, 5-MAPB), “classic” drugs (cocaine, ephedrine, THC, heroine), synthetic cannabinoids (JWH-081, AM-2201, JWH-210, MAM-2201), piperazines (o-CPP, p-CPP), tryptamines (5-MeO-MiPT), synthetic cathinones (N ethylpentylone), synthetic opioids (U-47700), aminoindanes (5-IAI), plant-based substances (Salvinorin-A) and “other” (methiopropamine). Three figures of merit (Selectivity, Precision and Robustness) were eval uated with retention index confidence intervals ranging from 0.5 to 20.6 i.u. and relative standard de viations in the range of 0.003% to 0.027% (repeatability) and 0.02% to 0.29% (intermediate precision). A general equation for estimating linear retention index variation as a function of retention time tolerance has been derived. This result in combination with a 26−3 III fractional factorial design allowed to conclude column polarity to be only statistically relevant factor as compared to gas flow, split ratio, injection tem perature, temperature program offset and column brand.pt_BR
dc.contributor.affiliationBrazilian Federal Police, National Institute of Criminalisticspt_BR
dc.contributor.affiliationBrazilian Health Regulatory Agencypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Chemistrypt_BR
dc.contributor.affiliationBrazilian Federal Police, National Institute of Criminalisticspt_BR
dc.contributor.affiliationBrazilian Federal Police, National Institute of Criminalisticspt_BR
dc.contributor.affiliationBrazilian Federal Police, National Institute of Criminalisticspt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Chemistrypt_BR
dc.description.unidadeInstituto de Química (IQ)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Químicapt_BR
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