| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Lima, Ana Luiza | - |
| dc.contributor.author | Pinho, Ludmila Alvim Gomes | - |
| dc.contributor.author | Chaker, Juliano Alexandre | - |
| dc.contributor.author | Pinho, Ludmila Alvim Gomes | - |
| dc.contributor.author | Barreto, Livia Cristina Lira de Sá | - |
| dc.contributor.author | Gratieri, Taís | - |
| dc.contributor.author | Gelfuso, Guilherme Martins | - |
| dc.contributor.author | Cunha Filho, Marcilio Sérgio Soares da | - |
| dc.date.accessioned | 2023-11-15T12:42:09Z | - |
| dc.date.available | 2023-11-15T12:42:09Z | - |
| dc.date.issued | 2020-08-17 | - |
| dc.identifier.citation | LIMA, Ana Luiza et al. Hot-melt extrusion as an advantageous technology to obtain effervescent drug products. Pharmaceutics, [S. l.], v. 12, n. 8, 799, 2020. DOI: https://doi.org/10.3390/pharmaceutics12080779. Disponível em: https://www.mdpi.com/1999-4923/12/8/779. Acesso em: 15 nov. 2023. | pt_BR |
| dc.identifier.uri | http://repositorio2.unb.br/jspui/handle/10482/46862 | - |
| dc.language.iso | por | pt_BR |
| dc.publisher | MDPI | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Hot-melt extrusion as an advantageous technology to obtain effervescent drug products | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Extrusão por fusão a quente | pt_BR |
| dc.subject.keyword | Medicamentos efervescentes | pt_BR |
| dc.rights.license | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | pt_BR |
| dc.identifier.doi | https://doi.org/10.3390/pharmaceutics12080779 | pt_BR |
| dc.description.abstract1 | Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug
products for the first time. For this, a combined mixture design was employed using paracetamol
as a model drug. Extrudates were obtained under reduced torque (up to 0.3 Nm) at 100 ◦C to
preserve the stability of the effervescent salts. Formulations showed vigorous and rapid effervescent
disintegration (<3 min), adequate flow characteristics, and complete solubilization of paracetamol
instantly after the effervescent reaction. Formulations containing PVPVA in the concentration range
of 15–20% m/m were demonstrated to be sensitive to accelerated aging conditions, undergoing
marked microstructural changes, since the capture of water led to the agglomeration and loss of their
functional characteristics. HPMC matrices, in contrast, proved to be resistant to storage conditions
in high relative humidity, showing superior performance to controls, including the commercial
product. Moreover, the combined mixture design allowed us to identify significant interactions
between the polymeric materials and the disintegrating agents, showing the formulation regions
in which the responses are kept within the required levels. In conclusion, this study demonstrates
that HME can bring important benefits to the elaboration of effervescent drug products, simplifying
the production process and obtaining formulations with improved characteristics, such as faster
disintegration, higher drug solubilization, and better stability. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-2177-8941 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-4801-2145 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-1924-7885 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-9167-6852 | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences, Laboratory of Food, Drug, and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences, Laboratory of Food, Drug, and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasília, Faculty of Ceilândia | pt_BR |
| dc.contributor.affiliation | University of Brasília, Faculty of Ceilândia | pt_BR |
| dc.contributor.affiliation | Federal University of Goiás, School of Pharmacy, Laboratory of Nanosystems and Drug Delivery Devices | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences, Laboratory of Food, Drug, and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences, Laboratory of Food, Drug, and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences, Laboratory of Food, Drug, and Cosmetics | pt_BR |
| dc.description.unidade | Faculdade de Ciências da Saúde (FS) | pt_BR |
| dc.description.unidade | Departamento de Farmácia (FS FAR) | pt_BR |
| dc.description.unidade | Faculdade UnB Ceilândia (FCE) | pt_BR |
| dc.description.unidade | Colegiado de Bases Biológicas e da Saúde (FCE-BASES) | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
|
