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dc.contributor.authorSousa Neto, Ivo Vieira de-
dc.contributor.authorTibana, Ramires Alsamir-
dc.contributor.authorPrestes, Jonato-
dc.contributor.authorSilva, Leonardo Gomes de Oliveira da-
dc.contributor.authorAlmeida, Jeeser Alves-
dc.contributor.authorFranco, Octavio Luiz-
dc.contributor.authorOliveira, Edilamar Menezes de-
dc.contributor.authorVoltarelli, Fabricio Azevedo-
dc.contributor.authorDurigan, João Luiz Quaglioti-
dc.contributor.authorSousa, Marcelo Valle de-
dc.contributor.authorRicart, Carlos André O.-
dc.contributor.authorBotelho, Katyelle-
dc.contributor.authorCastro, Mariana S-
dc.contributor.authorFontes, Wagner-
dc.contributor.authorMarqueti, Rita de Cassia-
dc.date.accessioned2022-10-26T23:46:37Z-
dc.date.available2022-10-26T23:46:37Z-
dc.date.issued2020-05-04-
dc.identifier.citationSOUSA NETO, Ivo Vieira de et al. Paternal resistance training induced modifications in the left ventricle proteome independent of offspring diet. Oxidative Medicine and Cellular Longevity, v, 2020 art. 5603580, 2020. DOI 10.1155/2020/5603580. Disponível em: https://www.hindawi.com/journals/omcl/2020/5603580/. Acesso em: 26 out. 2022.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/45072-
dc.language.isoInglêspt_BR
dc.rightsAcesso Abertopt_BR
dc.titlePaternal resistance training induced modifications in the left ventricle proteome independent of offspring dietpt_BR
dc.typeArtigopt_BR
dc.subject.keywordHerança genéticapt_BR
dc.subject.keywordObesidadept_BR
dc.subject.keywordHomens - saúde e higienept_BR
dc.subject.keywordEpigenéticapt_BR
dc.rights.licenseOxidative Medicine and Cellular Longevity - This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte:https://www.hindawi.com/journals/omcl/guidelines/. Acesso em: 26 out. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.1155/2020/5603580pt_BR
dc.description.abstract1Ancestral obesogenic exposure is able to trigger harmful effects in the offspring left ventricle (LV) which could lead to cardiovascular diseases. However, the impact of the father’s lifestyle on the offspring LV is largely unexplored. The aim of this study was to investigate the effects of 8 weeks of paternal resistance training (RT) on the offspring left ventricle (LV) proteome exposed to control or high-fat (HF) diet. Wistar rats were randomly divided into two groups: sedentary fathers and trained fathers (8 weeks, 3 times per week with weights secured to the animals’ tails). The offspring were obtained by mating with sedentary females. Upon weaning, male offspring were divided into 4 groups (5 animals per group): offspring from sedentary fathers, exposed to control diet (SFO-C); offspring from trained fathers, exposed to control diet (TFO-C); offspring from sedentary fathers, exposed to high-fat diet (SFO-HF); and offspring from trained fathers, exposed to highfat diet (TFO-HF). The LC-MS/MS analysis revealed 537 regulated proteins among groups. Offspring exposure to HF diet caused reduction in the abundance levels of proteins related to cell component organization, metabolic processes, and transport. Proteins related to antioxidant activity, transport, and transcription regulation were increased in TFO-C and TFO-HF as compared with the SFO-C and SFO-HF groups. Paternal RT demonstrated to be an important intervention capable of inducing significant effects on the LV proteome regardless of offspring diet due to the increase of proteins involved into LV homeostasis maintenance. This study contributes to a better understanding of the molecular aspects involved in transgenerational inheritance.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1479-5866pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0399-8817pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3409-8005pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9546-0525pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7101-312Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8077-8941pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7511-5289pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5140-8573pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9126-3882pt_BR
dc.contributor.emailmailto:ivoneto04@hotmail.compt_BR
dc.contributor.emailmailto:marqueti@gmail.compt_BR
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