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Universidade de Brasília
Use este identificador para citar ou linkar para este item: http://repositorio2.unb.br/jspui/handle/10482/45008
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dc.contributor.authorMachado, Camila Maria Longo-
dc.contributor.authorSkubal, Magdalena-
dc.contributor.authorHaedicke, Katja-
dc.contributor.authorPittella-Silva, Fabio-
dc.contributor.authorStater, Evan Paul-
dc.contributor.authorSilva, Thais Larissa Araujo de Oliveira-
dc.contributor.authorCosta, Erico Tosoni-
dc.contributor.authorMasotti, Cibele-
dc.contributor.authorOtake, Andreia Hanada-
dc.contributor.authorAndrade, Luciana Nogueira Sousa-
dc.contributor.authorJunqueira, Mara de Souza-
dc.contributor.authorHsiao-Ting Hsu-
dc.contributor.authorDas, Sudeep-
dc.contributor.authorMc Larney, Benedict-
dc.contributor.authorPratt, Edwin Charles-
dc.contributor.authorRomin, Yevgeniy-
dc.contributor.authorNing Fan-
dc.contributor.authorManova-Todorova, Katia-
dc.contributor.authorPomper, Martin-
dc.contributor.authorGrimm, Jan-
dc.date.accessioned2022-10-06T15:51:42Z-
dc.date.available2022-10-06T15:51:42Z-
dc.date.issued2022-
dc.identifier.citationMACHADO, Camila Maria Longo et al. PSMA-bearing extracellular vesicles secreted from prostate cancer convert the microenvironment to a tumor-supporting, pro-angiogenic state. bioRxiv preprint, 2022. DOI: https://doi.org/10.1101/2022.02.25.482024.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/45008-
dc.language.isoInglêspt_BR
dc.publisherbioRxiv preprintpt_BR
dc.rightsAcesso Abertopt_BR
dc.titlePSMA-bearing extracellular vesicles secreted from prostate cancer convert the microenvironment to a tumor-supporting, pro-angiogenic statept_BR
dc.typePreprintpt_BR
dc.subject.keywordPróstata - câncerpt_BR
dc.identifier.doihttps://doi.org/10.1101/2022.02.25.482024pt_BR
dc.description.abstract1Extracellular vesicles (EV) are comprised of vesicles budding from cell membranes and smaller intracellular vesicles shed by cells. EV play a role in remodeling the tumor microenvironment (TME) and support tumor progression. Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein with a carboxypeptidase function, frequently associated with poor clinical prognosis in prostate cancer (PCa). We previously identified an oncogenic PSMA signaling function in prostate cancer. Others demonstrated that EV isolated from the plasma of patients with high-grade PCa carry PSMA, but so far no pathophysiological effect has been associated with PSMA-bearing EV. Here we demonstrate that EV from PCa cells are able to transfer PSMA and its functionality to cells in the TME. The consequence of that EV-mediated PSMA transfer is an acute to long-term increased secretion of vascular endothelial growth factor-A (VEGF-A), angiogenin, pro-angiogenic and pro-lymphangiogenic mediators and increased 4E binding protein 1 (4EBP-1) phosphorylation in tumors. We compare EV from PCa cells with or without PSMA expression to address the role of PSMA-bearing EV in promoting pro-tumoral changes in the TME using classical molecular biology and novel molecular imaging approaches.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6122-1147pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3446-5415pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8825-5686pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9644-7098pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2679-1763pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7413-4675pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4462-0941pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1303-1220pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2735-1217pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2404-6543pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9393-204Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6165-7431pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6054-6983pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3649-6813pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0915-6696pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6753-3010pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5282-9385pt_BR
dc.contributor.affiliationUniversidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Patologia Molecular do Câncerpt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
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