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dc.contributor.authorSilva, Juliana Carvalho Rocha Alves da Silva-
dc.contributor.authorRamos, Doralina do Amaral Rabello-
dc.contributor.authorBravo, Martha Oliveira-
dc.contributor.authorAraujo, Antônio Lucena-
dc.contributor.authorOliveira, Diego Madureira de-
dc.contributor.authorOliveira, Fábio Morato de-
dc.contributor.authorRêgo, Eduardo Magalhães-
dc.contributor.authorPittella-Silva, Fabio-
dc.contributor.authorAraujo, Felipe de Saldanha-
dc.date.accessioned2022-10-04T10:44:49Z-
dc.date.available2022-10-04T10:44:49Z-
dc.date.issued2017-
dc.identifier.citationALVES‐SILVA, Juliana Carvalho et al. Aberrant levels of SUV39H1 and SUV39H2 methyltransferase are associated with genomic instability in chronic lymphocytic leukemia. Environmental and Molecular Mutagenesis, v. 58, n. 9, p. 654-661, 2017. DOI: http://dx.doi.org/10.1002/em.22128. Acesso em: 03 out. 2022.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/44977-
dc.language.isoInglêspt_BR
dc.publisherWileypt_BR
dc.rightsAcesso Restritopt_BR
dc.titleAberrant levels of SUV39H1 and SUV39H2 methyltransferase are associated with genomic instability in chronic lymphocytic leukemiapt_BR
dc.typeArtigopt_BR
dc.subject.keywordLeucemiapt_BR
dc.subject.keywordCromossomos - anomaliaspt_BR
dc.subject.keywordTelomerasept_BR
dc.subject.keywordMetiltransferasespt_BR
dc.identifier.doihttp://dx.doi.org/10.1002/em.22128pt_BR
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/em.22128pt_BR
dc.description.abstract1Chromosomal alterations are commonly detected in patients with chronic lymphocytic leukemia (CLL) and impact disease pathogenesis, prognosis, and progression. Telomerase expression (hTERT), its activity and the telomere length are other important predictors of survival and multiple outcomes in CLL. SUV39H and SUV420H enzymes are histone methyltransferases (HMTases) involved in several cellular processes, including regulation of telomere length, heterochromatin organization, and genome stability. Here, we investigated whether SUV39H1, SUV39H2, SUV420H1, SUV420H2, and hTERT are associated with genomic instability of CLL. SUV39H (1/2), SUV420H (1/2), and hTERT expression was determined in 59 CLL samples by real time PCR. In addition, ZAP-70 protein expression was evaluated by Flow Cytometry and patients’ karyotype was defined by Cytogenetic Analysis. Low expression of SUV39H1 was associated with the acquisition of altered and complex karyotypes. Conversely, high expression of SUV39H2 correlated with cytogenetic abnormalities in CLL patients. The pattern of karyotypic alterations differed in samples with detectable or undetectable hTERT expression. Furthermore, hTERT expression in CLL showed a correlation with transcript levels of SUV39H2, which, in part, can explain the association between SUV39H2 expression and cytogenetic abnormalities. Moreover, SUV39H1 correlated with SUV420H1 expression while SUV420H2 was associated with all other investigated HMTases. Our data show that the differential expression of SUV39H1 and SUV39H2 is associated with genomic instability and that the modulation of these HMTases can be an attractive approach to prevent CLL evolution.pt_BR
dc.contributor.affiliationUniversidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Patologia Molecular do Câncerpt_BR
dc.contributor.affiliationUniversidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Patologia Molecular do Câncerpt_BR
dc.contributor.affiliationUniversidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Farmacologia Molecularpt_BR
dc.contributor.affiliationUniversidade Federal de Pernambuco, Laboratório de Hematologiapt_BR
dc.contributor.affiliationUniversidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Patologia Molecular do Câncerpt_BR
dc.contributor.affiliationUniversidade de São Paulo, Laboratório de Hematologiapt_BR
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