Octovespin, a peptide bioinspired by wasp venom, prevents cognitive deficits induced by amyloid-β in Alzheimer’s disease mouse model

Camargo, Luana Cristina; Veras, Leticia Germina; Vaz, Gabriela; Souza, Adolfo Carlos Barros de; Mortari, Márcia Renata

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Campo DC	Valor	Idioma
dc.contributor.author	Camargo, Luana Cristina	-
dc.contributor.author	Veras, Leticia Germina	-
dc.contributor.author	Vaz, Gabriela	-
dc.contributor.author	Souza, Adolfo Carlos Barros de	-
dc.contributor.author	Mortari, Márcia Renata	-
dc.date.accessioned	2022-07-27T20:25:53Z	-
dc.date.available	2022-07-27T20:25:53Z	-
dc.date.issued	2022-03-11	-
dc.identifier.citation	CAMARGO, Luana Cristina et al. Octovespin, a peptide bioinspired by wasp venom, prevents cognitive deficits induced by amyloid-β in Alzheimer’s disease mouse model. Neuropeptides, v. 93, art. 102233, jun. 2022. DOI 10.1016/j.npep.2022.102233. Disponível em: https://www.sciencedirect.com/science/article/pii/S0143417922000087?via%3Dihub. Acesso em: 227 jul. 2022.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/44334	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Elsevier	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Octovespin, a peptide bioinspired by wasp venom, prevents cognitive deficits induced by amyloid-β in Alzheimer’s disease mouse model	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Alzheimer, Doença de	pt_BR
dc.subject.keyword	Peptídeos	pt_BR
dc.subject.keyword	Vespa - veneno	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.npep.2022.102233	pt_BR
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0143417922000087?via%3Dihub	pt_BR
dc.description.abstract1	Approximately 46.8 million people have been diagnosed worldwide with dementia, of which the most common type is Alzheimer’s disease (AD). Since the current AD treatment is incipient and limited, it is essential to develop new drugs to prevent AD. Considering that evolutionary pressure selected animal venom compounds that are very specific for a unique target, those can be a potential drug against AD. Octovespin was modified from occidentalin-1202, which is a peptide isolated from Polybia occidentalis wasp venom. In this context, this study evaluated the effect of treatment with octovespin against Amyloid-β (Aβ)-induced toxicity, which is postulated to be one of the main causes of AD, in both in vitro and in vivo tests. In vitro, octovespin was able to prevent Aβ aggregation in a ThT assay. In vivo, octovespin (0.15 nmol/animal) reverses memory impairment that is due to Aβ toxicity, in the Morris Water Maze and Novel Object Recognition Test. Our results suggested that octovespin is a potential drug for the treatment of AD, due to its ability to avoid Aβ aggregation in vitro and to prevent Aβ -induced memory deficit in mice.	pt_BR
dc.contributor.email	mailto:mmortari@unb.br	pt_BR
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