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dc.contributor.authorSousa, Herdson Renney de-
dc.contributor.authorOliveira Júnior, Getúlio Pereira de-
dc.contributor.authorFrazão, Stefânia de Oliveira-
dc.contributor.authorGorgonha, Kaio César de Melo-
dc.contributor.authorRosa, Camila Pereira-
dc.contributor.authorMelgaço Garcez, Emãnuella-
dc.contributor.authorLucas Júnior, Joaquim-
dc.contributor.authorCorreia, Amabel Fernandes-
dc.contributor.authorFreitas, Waleriano Ferreira de-
dc.contributor.authorBorges, Higor Matos-
dc.contributor.authorAlves, Lucas Gomes de Brito-
dc.contributor.authorPaes, Hugo Costa-
dc.contributor.authorTrilles, Luciana-
dc.contributor.authorLazera, Márcia dos Santos-
dc.contributor.authorTeixeira, Marcus de Melo-
dc.contributor.authorPinto Júnior, Vitor Laerte-
dc.contributor.authorFelipe, Maria Sueli Soares-
dc.contributor.authorCasadevall, Arturo-
dc.contributor.authorPereira, Ildinete Silva-
dc.contributor.authorAlbuquerque, Patrícia-
dc.contributor.authorNicola, André Moraes-
dc.date.accessioned2022-06-09T12:42:35Z-
dc.date.available2022-06-09T12:42:35Z-
dc.date.issued2022-04-12-
dc.identifier.citationSOUSA, Herdson Renney de et al. Faster cryptococcus melanization increases virulence in experimental and human cryptococcosis. Journal of Fungi, v. 8, n. 4, 393, 2022. DOI: https://doi.org/10.3390/jof8040393. Disponível em: https://www.mdpi.com/2309-608X/8/4/393. Acesso em: 08 jun. 2022.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/43910-
dc.language.isoPortuguêspt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleFaster cryptococcus melanization increases virulence in experimental and human cryptococcosispt_BR
dc.typeArtigopt_BR
dc.subject.keywordCryptococcus neoformanspt_BR
dc.subject.keywordCriptococosept_BR
dc.subject.keywordVirulência (Microbiologia)pt_BR
dc.subject.keywordMelaninapt_BR
dc.subject.keywordFagocitosept_BR
dc.rights.licenseCopyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)pt_BR
dc.identifier.doihttps://doi.org/10.3390/jof8040393pt_BR
dc.description.abstract1Cryptococcus spp. are human pathogens that cause 181,000 deaths per year. In this work, we systematically investigated the virulence attributes of Cryptococcus spp. clinical isolates and correlated them with patient data to better understand cryptococcosis. We collected 66 C. neoformans and 19 C. gattii clinical isolates and analyzed multiple virulence phenotypes and host–pathogen interaction outcomes. C. neoformans isolates tended to melanize faster and more intensely and produce thinner capsules in comparison with C. gattii. We also observed correlations that match previous studies, such as that between secreted laccase and disease outcome in patients. We measured Cryptococcus colony melanization kinetics, which followed a sigmoidal curve for most isolates, and showed that faster melanization correlated positively with LC3-associated phagocytosis evasion, virulence in Galleria mellonella and worse prognosis in humans. These results suggest that the speed of melanization, more than the total amount of melanin Cryptococcus spp. produces, is crucial for virulence.pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0001-6940-401Xpt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-1598-4191pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-8369-8680pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-8369-8680pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0001-8932-3954pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0003-1763-3464pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0003-0556-5310pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-9402-9167pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0001-8160-7784pt_BR
dc.description.unidadeFaculdade de Medicina (FMD)-
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