Title:	SARS-CoV-2/DENV co-infection : a series of cases from the Federal District, Midwestern Brazil
Authors:	Schulte, Heidi Luise Sousa, José Diego Brito Lacerda, Marcus Vinícius Guimarães de Naves, Luciana Ansaneli Gois, Eliana Teles de Fernandes, Mariana Sirimarco Lima, Valéria Paes Rassi, Carlos Henrique Reis Esselin Siracusa, Clara Correia de Sasaki, Lizandra Moura Paravidine Cerqueira, Selma Regina Penha Silva Albuquerque, Cleandro Pires de Reis, Ana Paula Monteiro Gomides Gomes, Ciro Martins Kurizky, Patricia Shu Mota, Licia Maria Henrique da Espindola, Laila Salmen
metadata.dc.identifier.orcid:	http://orcid.org/0000-0002-1886-868X
Assunto::	Covid-19 Dengue SARS-CoV-2 Coinfecções
Issue Date:	2021
Publisher:	BioMed Central
Citation:	SCHULTE, Heidi Luise et al. SARS-CoV-2/DENV co-infection: a series of cases from the Federal District, Midwestern Brazil. BMC Infectious Diseases, v. 21, 727, 2021. DOI: https://doi.org/10.1186/s12879-021-06456-2. Disponível em: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-06456-2#citeas. Acesso em: 24 dez. 2021.
Abstract:	Background: Since the novel coronavirus disease outbreak, over 179.7 million people have been infected by SARS-CoV-2 worldwide, including the population living in dengue-endemic regions, particularly Latin America and Southeast Asia, raising concern about the impact of possible co-infections. Methods: Thirteen SARS-CoV-2/DENV co-infection cases reported in Midwestern Brazil between April and September of 2020 are described. Information was gathered from hospital medical records regarding the most relevant clinical and laboratory findings, diagnostic process, therapeutic interventions, together with clinician-assessed outcomes and follow-up. Results: Of the 13 cases, seven patients presented Acute Undifferentiated Febrile Syndrome and six had pre-existing co-morbidities, such as diabetes, hypertension and hypopituitarism. Two patients were pregnant. The most common symptoms and clinical signs reported at first evaluation were myalgia, fever and dyspnea. In six cases, the initial diagnosis was dengue fever, which delayed the diagnosis of concomitant infections. The most frequently applied therapeutic interventions were antibiotics and analgesics. In total, four patients were hospitalized. None of them were transferred to the intensive care unit or died. Clinical improvement was verified in all patients after a maximum of 21 days. Conclusions: The cases reported here highlight the challenges in differential diagnosis and the importance of considering concomitant infections, especially to improve clinical management and possible prevention measures. Failure to consider a SARS-CoV-2/DENV co-infection may impact both individual and community levels, especially in endemic areas
metadata.dc.description.unidade:	Faculdade de Medicina (FMD)
Licença::	© The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
DOI:	https://doi.org/10.1186/s12879-021-06456-2
Appears in Collections:	Artigos publicados em periódicos e afins UnB - Covid-19

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