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dc.contributor.authorCunha, Leandro Rodrigues da-
dc.contributor.authorMuniz-Junqueira, Maria Imaculada-
dc.contributor.authorBorges, Tatiana Karla dos Santos-
dc.date.accessioned2021-12-20T11:52:01Z-
dc.date.available2021-12-20T11:52:01Z-
dc.date.issued2019-08-21-
dc.identifier.citationCUNHA, Leandro Rodrigues da; MUNIZ-JUNQUEIRA, Maria Imaculada; BORGES, Tatiana Karla dos Santos. Impact of polyphenols in phagocyte functions. Journal of Inflammation Research, [S.l.], v. 12, p. 205-217, 2019. DOI: https://doi.org/10.2147/JIR.S193749. Disponível em: https://www.dovepress.com/impact-of-polyphenols-in-phagocyte-functions-peer-reviewed-fulltext-article-JIR#. Acesso em: 20 dez. 2021.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/42592-
dc.language.isoInglêspt_BR
dc.publisherDove Presspt_BR
dc.rightsAcesso Abertopt_BR
dc.titleImpact of polyphenols in phagocyte functionspt_BR
dc.typeArtigopt_BR
dc.subject.keywordPolifenóispt_BR
dc.subject.keywordInflamaçãopt_BR
dc.subject.keywordMacrófagospt_BR
dc.subject.keywordCitocinaspt_BR
dc.rights.license© 2019 da Cunha et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/ terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).pt_BR
dc.identifier.doihttps://doi.org/10.2147/JIR.S193749pt_BR
dc.description.abstract1Polyphenols are a broad group of substances with potential health benefits found in plant species. Several of these compounds are capable of influencing the activation of intracellular signaling pathways, such as NF-kB, MAPK and JAK-STAT, responsible for the production of various inflammatory mediators such as tumor necrosis factor α (TNF-α) and interleukin 1 beta (IL-1β) and 12 (IL-12), enzymes involved in the production of reactive species such as inducible nitric oxide synthase (iNOS) and superoxide dehydrogenase (SOD), as well as enzymes involved in the production of eicosanoids, such as cyclooxygenase (COX) and lipoxygenase (LO). There is increased interest in the use of polyphenol-rich foods because of their immunomodulatory effect; however, the mechanisms used during macrophage responses are extremely complex and little is known about the effects of polyphenols on these cells. As such, this review summarizes the current view of polyphenol influences on macrophages.pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-9006-4619pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-6813-6276pt_BR
dc.description.unidadeFaculdade de Medicina (FMD)-
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