Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys

Oliveira, André Wagner Carvalho de; Pacheco, Jéssica V. N.; Costa, Clara de Sena; Aquino, Jéssica; Maior, Rafael Plakoudi Souto; Barros, Marilia

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Campo DC	Valor	Idioma
dc.contributor.author	Oliveira, André Wagner Carvalho de	-
dc.contributor.author	Pacheco, Jéssica V. N.	-
dc.contributor.author	Costa, Clara de Sena	-
dc.contributor.author	Aquino, Jéssica	-
dc.contributor.author	Maior, Rafael Plakoudi Souto	-
dc.contributor.author	Barros, Marilia	-
dc.date.accessioned	2021-11-25T12:07:11Z	-
dc.date.available	2021-11-25T12:07:11Z	-
dc.date.issued	2021-10-16	-
dc.identifier.citation	OLIVEIRA, André W. C. et al. Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys. Pharmacology Biochemistry and Behavior, v. 21, 173300, dez. 2021. DOI: https://doi.org/10.1016/j.pbb.2021.173300.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/42452	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Elsevier Inc.	-
dc.rights	Acesso Restrito	pt_BR
dc.title	Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Sagui	pt_BR
dc.subject.keyword	Memória de reconhecimento	pt_BR
dc.subject.keyword	Escopolamina	pt_BR
dc.subject.keyword	MK-801	pt_BR
dc.subject.keyword	Donepezila	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.pbb.2021.173300	pt_BR
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/abs/pii/S0091305721001994#!	pt_BR
dc.description.abstract1	The spontaneous object recognition (SOR) task is one of the most widely used behavioral protocols to assess visual memory in animals. However, only recently was it shown that nonhuman primates also perform well on this task. Here we further characterized this new monkey recognition memory test by assessing the performance of adult marmosets after an acute systemic administration of two putative amnesic agents: the competitive muscarinic acetylcholine receptor antagonist scopolamine (SCP; 0.05 mg/kg) and the noncompetitive N-methyl-d-aspartate glutamate receptor antagonist MK-801 (0.015 mg/kg). We also determined whether the acetylcholinesterase inhibitor donepezil (DNP; 0.50 mg/kg), a clinically-used cognitive enhancer, reverses memory deficits caused by either drug. The subjects had an initial 10 min sample trial where two identical neutral objects could be explored. After a 6 h retention interval, recognition was based on an exploratory preference for a new rather than familiar object during a 10 min test trial. Both SCP and MK-801 impaired the marmosets' performance on the SOR task, as both objects were explored equivalently. Co-administration of 0.50 mg/kg of DNP reversed the SCP- but not the MK-801-induced memory deficit. These results indicate that cholinergic and glutamatergic pathways mediate object recognition memory in the monkey SOR task.	pt_BR
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