Título:	Tucum-do-cerrado (Bactris setosa Mart.) modulates oxidative stress, inflammation, and apoptosis-related proteins in rats treated with azoxymethane
Autor(es):	Campos, Natália Aboudib Cunha, Marcela de Sá Barreto da Arruda, Sandra Fernandes
ORCID:	http://orcid.org/0000-0003-1518-2217 http://orcid.org/0000-0002-1388-033X
Assunto:	Tucum Stress oxidativo Inflamação Proteínas
Data de publicação:	14-Nov-2018
Editora:	PLoS ONE
Referência:	CAMPOS, Natália A.; CUNHA, Marcela S. B. da; ARRUDA, Sandra F. Tucum-do-cerrado (Bactris setosa Mart.) modulates oxidative stress, inflammation, and apoptosis-related proteins in rats treated with azoxymethane. PLoS One, v. 13, n. 11, e0206670, 2018. DOI: https://doi.org/10.1371/journal.pone.0206670. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206670. Acesso em: 23 nov. 2021.
Abstract:	Oxidative and inflammatory responses play an important role in the development and prevention of cancer, with both responses being modulated by phytochemical compounds. This study investigated the chemopreventive effect of tucum-do-cerrado fruit in rats treated with azoxymethane. Wistar rats were treated for 12 weeks with: a control diet (CT); a control diet + AOM (CT/DR); a control diet + 15% tucum-do-cerrado (TU); or a control diet + 15% tucum-do-cerrado + AOM (TU/DR). The association of tucum-do-cerrado and AOM (TU/ DR) increased glutathione-S-transferase activity, decreased MDA levels, increased levels of COX2, TNFα and BAX, and decreased Bcl2/Bax ratio, compared to the CT/DR group. Carbonyl levels, IL-1β and IL-6 mRNA levels, and aberrant crypt foci showed no difference between the treatments. In conclusion, tucum-do-cerrado reduced lipid oxidative damage, induced a pro-inflammatory effect, and promoted a pro-apoptotic “environment” in rats treated with AOM; however no changes in aberrant crypts were observed.
Licença:	Copyright: © 2018 Campos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI:	https://doi.org/10.1371/journal.pone.0206670
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