Título:	Characterization of the cicatrization process in diabetic foot ulcers based on the production of reactive oxygen species
Autor(es):	López Delis, Alberto Rosa, Suélia de Siqueira Rodrigues Fleury Souza, Paulo Eduardo Narcizo de Carneiro, Marcella Lemos Brettas Rosa, Mário Fabrício Fleury Macedo, Yasmin Carneiro Lobo Souza, Fabiane Hiratsuka Veiga Rocha, Adson Ferreira da
ORCID:	http://orcid.org/0000-0002-0826-5914 http://orcid.org/0000-0002-1247-9050 http://orcid.org/0000-0002-4289-8678 http://orcid.org/0000-0002-6165-0969 http://orcid.org/0000-0002-4821-9007 http://orcid.org/0000-0003-2778-4100 http://orcid.org/0000-0002-5300-5038 http://orcid.org/0000-0003-4532-1791
Assunto:	Diabéticos Pés - ferimentos e lesões Cicatrização de feridas Úlceras Radicais livres (Química)
Data de publicação:	2018
Editora:	Hindawi
Referência:	LÓPEZ DELIS, Alberto et al. Characterization of the cicatrization process in diabetic foot ulcers based on the production of reactive oxygen species. Journal of Diabetes Research, v. 2018, p. 1-10, 2018. Disponível em: https://www.hindawi.com/journals/jdr/2018/4641364/. Acesso em: 27 maio 2020.
Abstract:	The present study aims at evaluating the correlation between the free radical formation and the healing action of lower limbs’ ulcers in a randomized controlled trial with the use of an adhesive derived from natural latex associated with a light-emitting diode (LED) circuit. The sample consists of 15 participants with lower limb lesions divided into three groups: group 1 case (5 participants) received the proposed dressing system adhesive of the natural latex associated with the LED circuit; group 2 control (5 participants) received the dressings at home performed by nurses according to and established by the clinic of wounds (treated with calcium alginate or silver foam); and group 3 (5 participants) also received the dressing in their homes with the use of the dressing adhesive derived from the natural latex associated with the LED circuit. The collected data were analyzed qualitatively and quantitatively by electron paramagnetic resonance for determination of free radical formation. Kruskal-Wallis statistical test was used to evaluate the effect of treatment on the lower limb’s ulcer cicatrization process and its correlation with free radical. The results obtained corroborated the hypothesis about the reduction of the quantity of these molecules in the end of treatment related to the healing wound.
Unidade Acadêmica:	Faculdade UnB Gama (FGA)
Licença:	Copyright © 2018 Alberto López-Delis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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